Cecile Hoover Edwards

Much of Edwards' career focused on the eating habits of pregnant African-American women.[1] In a paper that was published in May 1953, Edwards partook in a study that attempted to analyze the effects of dietary supplements during the pregnancies of anemic women. The women were given either high mineral, high protein or high vitamin supplements. Results showed that women across all three conditions in study were showing the recommended intake levels of calories, proteins, calcium, iron, vitamin A and riboflavin. Moreover, these women also had higher red blood cell counts as well as hemoglobin concentrations, following the study. Several correlative conclusions were drawn, among them that the occurrences of birth-related complications in pregnant women with poor diets were higher than in pregnant women who had better diets. Additionally, good diets were correlated with an increase in infant length and weight. Edwards noted that the dietary supplements used in this experiment were both relatively inexpensive and common. She suggested that pregnant women of lower incomes maintain a highly nutritive diet based on these cheap and available foods.[8]

Another key point of Edward's focus was on the amino acid composition of foods, especially vegetables, with the goal of finding low-cost foods that were optimal for protein production.[2] Based on a study performed in India, where school children who consumed dietary supplements of the aforementioned nature had favorable gains in height, weight and hemoglobin, Edwards oversaw a similar experiment in Alabama. School children received low-cost dietary supplements within their school lunches, and over a six-month period, their heights, weights and scholastic scores were recorded. In order to calculate the nutritive value of the meals the children were eating, nutrients such as protein, calcium, vitamin A and vitamin D were measured. Children who received dietary supplements showed a considerable increase in the majority of these nutrients, and also received higher academic evaluations from their teachers; they were more alert and paid better attention, for example.[9]

She had a particular interest in the metabolism of the amino acid methionine, and starting in the 1950s, led an 18-year study for the National Institutes of Health on this topic.[1] In addition to that, Edwards was interested in postoperative dieting, due to the loss of tissue protein that is observed during surgeries. She was involved in a study that measured how well following surgery adult rats were able to absorb methionine (whose methyl group is used in a variety of biological functions). Ultimately, the rats that underwent surgery had a smaller uptake of methionine, specifically in the tissues that had been affected during the surgery. Moreover, Edwards observed that in the two weeks following surgery, the radio labeled plasma and tissue proteins in the rats showed greater activity by the alpha carbon of the methionine, as opposed to the methyl carbon.[10]

In the late 1980s Edwards studied historical dietary patterns in the South, identifying inexpensive traditional dishes that were sources of protein, and developing nutrition plans reducing the amount of fat in African-American cuisine.[1][2] She oversaw a study that assessed amino acid quality, nitrogen, and moisture content in a variety of common foods such as flour, cream cheese and lima beans. The purpose of this experiment was to suggest dietary complementation of particular foods, such that a consumer was focusing not just on overall high amino acid intake, but also on the quality of intake. For this reason, cystine and tyrosine quantities were studied as well, because the two share similar biological characteristics with methionine and phenylalanine, respectively. Acid hydrolyzates as well as microbiological assays were used in the quantification of amino acid content in the foods. Edwards observed differences in amino acid content between similar foods; for example, she found that bologna contained more amino acids than frankfurters and that lima beans had more cysteine and valine than pork and beans. The purpose of this study, Edwards noted, was to provide knowledge on amino acid content, such that people can consciously pair certain foods together for optimal intake.[11]

Edwards, in addition, also partook in a study that assessed the extent to which the body responds to lacking amounts of necessary proteins via intake. The results supported the conclusion that the body compensates for how much protein is added; for example, when the minimal protein intake was met, the body responded by conserving methionine catabolism. And additionally, when certain amino acids were lacking, they were synthesized as well as reused, in lieu of excretion. Edwards concluded overall that around 46 grams of protein a day are required in the continued maintenance of the adult male. She also made note that wheat-based diets do provide adequate dietary supplementation, which is an important conclusion given that the geography of various places in the world cause those places to be heavily wheat-based.[12]

Edwards opposed hereditarian positions in the nature and nurture debate such as those of Arthur Jensen which credited genes as the dominant factor in intelligence; she concluded that social and environmental factors were at least as responsible as heredity in influencing intelligence.[1] Furthermore, Edwards worked to spread knowledge about issues such as childcare and financial budgeting to lower income and disadvantaged populations.[6]

In a review Edwards published in 1995, she introduced a concept of population approach, which she believed was how the medical system should treat patients, by viewing and taking into account their social, economic and cultural environments. Moreover, she looked specifically into hypertension within the Black American demographic, and named weight control, reduced sodium chloride intake and physical activities as ways of prevention. At the same time, she cited social factors as possible causes for the higher hypertension rates among Black Americans than among White Americans. For example, Edwards noted that generally and comparatively, Black Americans were more likely to be poor and more likely to live farther from medical treatment. Additionally, she stated that Black Americans suffered from greater psychosocial stress and other social strains due to racism, and that these factors and their correlation towards hypertension required further research.[13]