Centaurin, alpha 1

Arf-GAP with dual PH domain-containing protein 1 is a protein that in humans is encoded by the ADAP1 gene.[5][6]

ADAP1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesADAP1, CENTA1, GCS1L, p42IP4, Centaurin, alpha 1, ArfGAP with dual PH domains 1
External IDsOMIM: 608114 MGI: 2442201 HomoloGene: 55997 GeneCards: ADAP1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7p22.3Start897,900 bp[1]
End955,407 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11033

231821

Ensembl

ENSG00000105963

ENSMUSG00000056413

UniProt

O75689

n/a

RefSeq (mRNA)

NM_006869
NM_001284308
NM_001284309
NM_001284310
NM_001284311

NM_172723

RefSeq (protein)

NP_001271237
NP_001271238
NP_001271239
NP_001271240
NP_006860

n/a

Location (UCSC)Chr 7: 0.9 – 0.96 MbChr 5: 139.27 – 139.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

Centaurin, alpha 1 has been shown to interact with:

Model organisms

Model organisms have been used in the study of ADAP1 function. A conditional knockout mouse line called Adap1tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[11] Male and female animals underwent a standardized phenotypic screen[12] to determine the effects of deletion.[13][14][15][16] Additional screens performed:

  • In-depth immunological phenotyping[17]
  • in-depth bone and cartilage phenotyping[18]

References

  1. GRCh38: Ensembl release 89: ENSG00000105963 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000056413 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Venkateswarlu K, Oatey PB, Tavaré JM, Jackson TR, Cullen PJ (Jun 1999). "Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1". The Biochemical Journal. 340 (2): 359–63. doi:10.1042/0264-6021:3400359. PMC 1220257. PMID 10333475.
  6. "Entrez Gene: CENTA1 centaurin, alpha 1".
  7. Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/s0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
  8. Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
  9. Dubois T, Zemlickova E, Howell S, Aitken A (Feb 2003). "Centaurin-alpha 1 associates in vitro and in vivo with nucleolin". Biochemical and Biophysical Research Communications. 301 (2): 502–8. doi:10.1016/s0006-291x(02)03010-3. PMID 12565890.
  10. Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (Aug 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications. 307 (3): 459–65. doi:10.1016/s0006-291x(03)01187-2. PMID 12893243.
  11. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  12. "International Mouse Phenotyping Consortium".
  13. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  14. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  15. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  16. White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  17. "Infection and Immunity Immunophenotyping (3i) Consortium".
  18. "OBCD Consortium".

Further reading

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