Cielo de Angelina

• Bea Binene as Angelina Nantes[2]

An orphan girl who was left on the doorstep of an orphanage run by nuns, one stormy night. There, she grows up with Marco, who also serves as her older brother. Marco also helps Angelina to search for her parents. But just as they were on to something, Angelina is adopted and thus begins her life of torment.[3]

• Jake Vargas as Marco Sevilla

When he was a little boy when he witnessed Angelina's arrival as a baby in El Cielo. Since then, he has acted as an older brother figure to her, especially when her best friend, Julie was adopted. He will soon find himself falling in love with Angelina. But under the circumstances, his love will remain undeclared and unrequited.[4]

• Gloria Romero as Sor Margaret

The head nun who owns and runs the El Cielo Shelter for Destitute Women and Abandoned Children, the orphanage where Angelina grew up. She also holds the key to unraveling Angelina's mysterious past.

• Jessa Zaragoza as Congresswoman Theresa Alfonso

A successful woman with a traumatic past. Despite her success and wealth, she feels that there's a big part of her life that is missing.[5]

• Gerald Madrid as Benjamin "Benjie" Nantes

Angelina’s adoptive father. He is wealthy architect who will become the hapless victim of Czarina’s evilness.

• Isabel Granada as Czarina

The scheming arch-enemy of the story. She is Benjie Nantes' vindictive mistress who will stop at nothing to get what she wants. She and her daughter, Rhoda will make life difficult for Angelina.[6]

• Baby O'Brien as Miriam "Mamer" Dela Guardia

A wealthy and influential woman who has a big heart for children. She adopted Julie/Marian in two purposes – to have a child she can call her own and to have an heir for her vast properties.

• Victor Basa as Frank Cordero

The resident doctor of El Cielo Shelter. Dr. Cordero is a wealthy and handsome doctor who has a big heart for the less fortunate. He eventually falls in love with Elaine, a single mother.[7]

• Roxanne Barcelo as Elaine

A mother and a resident of El Cielo Shelter for Destitute Women and Abandoned Children. She rebuilds her life after being abandoned by her boyfriend with the help of Dr. Frank, her newfound love.

• Hiro Peralta as James Aragon

Considered as "Mr. Campus Heartthrob" of St. Isadore, James is a classic "born with a silver spoon in his mouth" – bratty and arrogant. He eventually falls in love with Angelina. But the latter's closeness with Marco makes him jealous and will cause friction between them.

• Ashley Ortega as Marian "Julie" Dela Guardia

Julie and Angelina form a bond as children in El Cielo, only to lose each other as they grow up.

• Yassi Pressman as Rhoda

Czarina's only daughter, and like her mother, she is also a self-centered and scheming young lady whose habit is making Angelina's life unbearable.[8]

• Stephanie Sol as Perlita Zulueta

The supportive friend of Angelina and the mother of Marco. The best friend of Theresa, she is the only surrogate not to be killed, but failed by the one of the certain's guards. She is caring towards Angelina because she reminds her of Theresa's changed.

• Jillian Ward as young Angelina Nantes
• Miggy Jimenez as young Marco Sevilla
• Elijah Alejo as young Marian "Julie" Dela Guardia
• Rina Reyes as Sister Elena
• Debraliz Borres as Sister Susan
• Kathleen Hermosa as Marilyn Nantes
• Izzy Trazona-Aragon as Dena
• Vangie Labalan as Rosario
• Biboy Ramirez as Armando
• Renz Valerio as Keith
• Lindt Johnston as Kelly
• Nicole Dulalia as Bernie
• Jolo Romualdez as Randy
• Maey Bautista as Yaya Simang
• Derick Lim as Elly
• Jak Roberto as Andrei
• Marco Masa

GMA Films chose teen actors Bea Binene and Jake Vargas to lead their first television venture. Before they started filming the series, Binene and Vargas talked about the acting they will do in the soap [including the approach to their characters]. “We didn’t attend workshops. But we are used to doing drama. We already have an idea on what to do. That’s perhaps our preparation,” Vargas said.[15]

Jessa Zaragoza was chosen to play Theresa Alfonso, the main protagonist's biological mother. The singer-actress stated that it's her first time doing a character of a politician and revealed that Lucy Torres is her peg for her role.[5] Mico Palanca was originally cast as Benjamin Nantes, but due to “unprofessionalism” and “he doesn’t want to play a father role” issues, he was replaced by Gerald Madrid. Drastic revisions were made to the script. The writers found that they had to adjust the character of Benjamin to suit for Madrid.[16]

The classic Filipino inspirational song, “Natutulog Ba Ang Diyos?” (lit. Is God Sleeping?) was used as the series’ theme song. It was written and composed by Nonong Buencamino. The lyrics tell of a person asking questions why difficulties exists in life, was God really sleeping.

The show used seven versions of the song throughout its run: the main theme, which was performed by Jonalyn Viray; duet versions of the song performed by Jillian Ward and Viray, and Ward and Bea Binene; solo versions of Binene, Jessa Zaragoza, and Jake Vargas; and the trio version of song performed by Viray, Ward and Binene.[17]