Clodagh O'Shea
Clodagh C. O'Shea is a professor of molecular and cell biology and current Wicklow Chair at the Salk Institute for Biological Sciences and a scholar at the Howard Hughes Medical Institute.[1]
Clodagh O'Shea | |
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| Nationality | Irish |
| Alma mater | University College Cork, Imperial College London, UCSF Comprehensive Cancer Center |
| Known for | Virally targeting cancer cells |
| Awards | Allen Distinguished Investigator Award, Howard Hughes Medical Institute Faculty Scholar, W. M. Keck Medical Research Program Award, Rose Hills Fellow, Science/NSF International Science & Visualization Challenge, People's Choice, Anna Fuller Award for Cancer Research, Kavli Frontiers Fellow, National Academy of Sciences |
| Scientific career | |
| Fields | Cancer Biology |
| Institutions | Salk Institute for Biological Studies |
Education
O'Shea has a BS in biochemistry and microbiology from University College Cork, Ireland and a PhD from Imperial College London. She was a Postdoctoral Fellow at the UCSF Comprehensive Cancer Center, San Francisco, United States.[1]
Selected publications
- O'Shea, Clodagh C.; Choi, Serah; McCormick, Frank; Stokoe, David (2 May 2005). "Adenovirus Overrides Cellular Checkpoints for Protein Translation". Cell Cycle. 4 (7): 883–888. doi:10.4161/cc.4.7.1791. PMID 15970698.
- Ringshausen, Ingo; O'Shea, Clodagh C.; Finch, Andrew J.; Swigart, Lamorna Brown; Evan, Gerard I. (December 2006). "Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo". Cancer Cell. 10 (6): 501–514. doi:10.1016/j.ccr.2006.10.010. PMID 17157790.
- Heimbucher, Thomas; Liu, Zheng; Bossard, Carine; McCloskey, Richard; Carrano, Andrea C.; Riedel, Christian G.; Tanasa, Bogdan; Klammt, Christian; Fonslow, Bryan R.; Riera, Celine E.; Lillemeier, Bjorn F. (July 2015). "The Deubiquitylase MATH-33 Controls DAF-16 Stability and Function in Metabolism and Longevity". Cell Metabolism. 22 (1): 151–163. doi:10.1016/j.cmet.2015.06.002. PMC 4502596. PMID 26154057.
- Shah, Govind A.; O'Shea, Clodagh C. (August 2015). "Viral and Cellular Genomes Activate Distinct DNA Damage Responses". Cell. 162 (5): 987–1002. doi:10.1016/j.cell.2015.07.058. PMC 4681434. PMID 26317467.
- Higginbotham, Jennifer M.; O'Shea, Clodagh C. (15 October 2015). Imperiale, M. J. (ed.). "Adenovirus E4-ORF3 Targets PIAS3 and Together with E1B-55K Remodels SUMO Interactions in the Nucleus and at Virus Genome Replication Domains". Journal of Virology. 89 (20): 10260–10272. doi:10.1128/JVI.01091-15. ISSN 0022-538X. PMC 4580165. PMID 26223632.
- Ou, Horng D.; Deerinck, Thomas J.; Bushong, Eric; Ellisman, Mark H.; O'Shea, Clodagh C. (November 2015). "Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy". Methods. 90: 39–48. doi:10.1016/j.ymeth.2015.06.002. PMC 4655137. PMID 26066760.
- Tufail, Yusuf; Cook, Daniela; Fourgeaud, Lawrence; Powers, Colin J.; Merten, Katharina; Clark, Charles L.; Hoffman, Elizabeth; Ngo, Alexander; Sekiguchi, Kohei J.; O'Shea, Clodagh C.; Lemke, Greg (February 2017). "Phosphatidylserine Exposure Controls Viral Innate Immune Responses by Microglia". Neuron. 93 (3): 574–586.e8. doi:10.1016/j.neuron.2016.12.021. PMC 5600182. PMID 28111081.
- Ou, Horng D.; Phan, Sébastien; Deerinck, Thomas J.; Thor, Andrea; Ellisman, Mark H.; O'Shea, Clodagh C. (28 July 2017). "ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells". Science. 357 (6349): eaag0025. doi:10.1126/science.aag0025. ISSN 0036-8075. PMC 5646685. PMID 28751582.
- Dekker, Job; Belmont, Andrew S.; Guttman, Mitchell; Leshyk, Victor O.; Lis, John T.; Lomvardas, Stavros; Mirny, Leonid A.; O'Shea, Clodagh C.; Park, Peter J.; Ren, Bing; Politz, Joan C. Ritland; Shendure, Jay; Zhong, Sheng (14 September 2017). "The 4D nucleome project". Nature. 549 (7671): 219–226. doi:10.1038/nature23884. PMC 5617335. PMID 28905911.
Awards[2]
- 2018 Paul G. Allen Frontiers Group's Allen Distinguished Investigator[3]
- 2016 Howard Hughes Medical Institute Faculty Scholar
- 2014 W. M. Keck Medical Research Program Award
- 2014 Rose Hills Fellow
- 2011Science/NSF International Science & Visualization Challenge, People's Choice
- 2011 Anna Fuller Award for Cancer Research
- 2010, 2011, 2012 Kavli Frontiers Fellow, National Academy of Sciences
- 2009 Sontag Distinguished Scientist Award
- 2009 American Cancer Society Research Scholar Award
- 2008 ACGT Young Investigator Award for Cancer Gene Therapy
- 2008 Arnold and Mabel Beckman Young Investigators Award[4]
- 2008 William Scandling Assistant Professor, Developmental Chair
- 2007 Emerald Foundation Scholar
References
- "Clodagh O'Shea". Salk Institute. Retrieved March 14, 2020.
- "Clodagh O'Shea". Salk Institute for Biological Studies. Retrieved 2020-03-25.
- "Assembling DNA into cromatin". Salk News.
- "Awarded Scientists". Arnold and Mabel Beckman Foundation. Retrieved 2020-02-26.
Further reading
- "Guest Editor". Oncogene. 24 (52): 7635. 21 November 2005. doi:10.1038/sj.onc.1209036.
- Robbins, Gary (28 June 2010). "Meet the Scientist". The San Diego Union-Tribune. p. E-2.
- Fikes, Bradley J. (27 July 2017). "Salk Institute, UCSD scientists decode DNA's 3D shape". The San Diego Union-Tribune.
- Pickett, Mallory (21 April 2019). "I Want What My Male Colleague Has, and That Will Cost a Few Million Dollars". The New York Times Magazine. p. 50.
Clodagh O'Shea was promoted to full professor in February 2018, the first woman to achieve that rank [at the Salk Institute] since [Beverly M.] Emerson in 1999.
- Perkel, Jeffrey M. (6 May 2019). "The new techniques revealing the varied shapes of chromatin". Nature. 569 (7755): 293–294. doi:10.1038/d41586-019-01426-w. PMID 31061461.
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