Clostridium scindens

Clostridium scindens is a species of bacteria in the genus Clostridium. Samples of this species were first isolated from human feces.[1]

Clostridium scindens
Scientific classification
Kingdom:
Bacteria
Phylum:
Firmicutes
Class:
Clostridia
Order:
Clostridiales
Family:
Clostridiaceae
Genus:
Clostridium
Species:
C. scindens
Binomial name
Clostridium scindens
Hall & O'Toole, 1935

Clostridia (members of the genus Clostridium) are anaerobic, motile bacteria, ubiquitous in nature, and especially prevalent in soil. Under the microscope, they appear as long, irregular (often drumstick- or spindle-shaped) cells with a bulge at their terminal ends.

C. scindens is capable of converting primary bile acids to toxic secondary bile acids, as well as converting glucocorticoids to androgens by side-chain cleavage.[2]

C. scindens may become established in the human colon, and its presence is associated with resistance to C. difficile infection, due to production of secondary bile acids which inhibit the growth of “C. difficile”.[3]

References
  1. MORRIS, G. N.; WINTER, J.; CATO, E. P.; RITCHIE, A. E.; BOKKENHEUSER, V. D. (1 October 1985). "Clostridium scindens sp. nov., a Human Intestinal Bacterium with Desmolytic Activity on Corticoids". International Journal of Systematic Bacteriology. 35 (4): 478–481. doi:10.1099/00207713-35-4-478.
  2. Ridlon, J. M.; Ikegawa, S.; Alves, J. M. P.; Zhou, B.; Kobayashi, A.; Iida, T.; Mitamura, K.; Tanabe, G.; Serrano, M.; De Guzman, A.; Cooper, P.; Buck, G. A.; Hylemon, P. B. (15 June 2013). "Clostridium scindens: a human gut microbe with a high potential to convert glucocorticoids into androgens". The Journal of Lipid Research. 54 (9): 2437–2449. doi:10.1194/jlr.M038869. PMC 3735941. PMID 23772041.
  3. Buffie, Charlie G.; Bucci, Vanni; Stein, Richard R.; McKenney, Peter T.; Ling, Lilan; Gobourne, Asia; No, Daniel; Liu, Hui; Kinnebrew, Melissa; Viale, Agnes; Littmann, Eric; Van Den Brink, Marcel R. M.; Jenq, Robert R.; Taur, Ying; Sander, Chris; Cross, Justin R.; Toussaint, Nora C.; Xavier, Joao B.; Pamer, Eric G. (2015). "Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile". Nature. 517 (7533): 205–208. Bibcode:2015Natur.517..205B. doi:10.1038/nature13828. PMC 4354891. PMID 25337874.


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