Collagen-induced arthritis

Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.[1]

Collagen-induced arthritis

CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen.[2]

In rats, only one injection is needed, but mice are normally injected twice.[3]

References
  1. Williams, RO (2004). Collagen-induced arthritis as a model for rheumatoid arthritis. Methods Mol Med. 98. pp. 207–16. doi:10.1385/1-59259-771-8:207. ISBN 978-1-59259-771-0. PMID 15064442.
  2. Brand, DD; Latham, KA; Rosloniec, EF (2007). "Collagen-induced arthritis". Nat Protoc. 2 (5): 1269–75. doi:10.1038/nprot.2007.173. PMID 17546023.
  3. Arthritis in mice induced by a single immunisation with collagen


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