Crotonyl-CoA carboxylase/reductase
Crotonyl-CoA carboxylase/reductase (EC 1.3.1.85, CCR, crotonyl-CoA reductase (carboxylating)) is an enzyme with systematic name (2S)-ethylmalonyl-CoA:NADP+ oxidoreductase (decarboxylating).[1][2] This enzyme catalyses the following chemical reaction
- (2S)-ethylmalonyl-CoA + NADP+ (E)-but-2-enoyl-CoA + CO2 + NADPH + H+
| Crotonyl-CoA carboxylase/reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crotonyl-CoA carboxylase/reductase tetramer, Streptomyces sp. NRRL 2288 | |||||||||
| Identifiers | |||||||||
| EC number | 1.3.1.85 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The reaction is catalysed in the reverse direction.
References
- Erb TJ, Berg IA, Brecht V, Müller M, Fuchs G, Alber BE (June 2007). "Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway". Proceedings of the National Academy of Sciences of the United States of America. 104 (25): 10631–6. doi:10.1073/pnas.0702791104. PMC 1965564. PMID 17548827.
- Erb TJ, Brecht V, Fuchs G, Müller M, Alber BE (June 2009). "Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase". Proceedings of the National Academy of Sciences of the United States of America. 106 (22): 8871–6. doi:10.1073/pnas.0903939106. PMC 2689996. PMID 19458256.
External links
- Crotonyl-CoA+carboxylase/reductase at the US National Library of Medicine Medical Subject Headings (MeSH)
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