Ctgf/hcs24 CAESAR
ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor (CTGF) messenger RNA.[1] This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).
| ctgf/hcs24 CAESAR | |
|---|---|
 Predicted secondary structure and sequence conservation of CAESAR | |
| Identifiers | |
| Symbol | CAESAR |
| Rfam | RF00172 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Eukaryota |
| SO | SO:0000233 |
| PDB structures | PDBe |
The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised[1] and subsequently the minimal RNA element responsible for repression was identified[2] This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).
The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression.[3]
References
- Kubota S, Hattori T, Nakanishi T, Takigawa M (1999). "Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene". FEBS Lett. 450 (1–2): 84–88. doi:10.1016/S0014-5793(99)00480-9. PMID 10350062.
- Kubota S, Kondo S, Eguchi T, et al. (2000). "Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions". Oncogene. 19 (41): 4773–4786. doi:10.1038/sj.onc.1203835. PMID 11032028.
- Mukudai Y, Kubota S, Takigawa M (2003). "Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species". Biol. Chem. 384 (1): 1–9. doi:10.1515/BC.2003.001. PMID 12674494.
External links
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