Cyclic pyranopterin monophosphate

Cyclic pyranopterin monophosphate
Names
	Other names cPMP; Precursor Z
Identifiers
CAS Number	150829-29-1 ;
3D model (JSmol)	Interactive image;
ChemSpider	17221217 ;
PubChem CID	16061579;
UNII	4X7K2681Y7 ;
CompTox Dashboard (EPA)	DTXSID90934067 ;
	InChI InChI=1S/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1 Key: CZAKJJUNKNPTTO-AJFJRRQVSA-N ; InChI=1/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1 Key: CZAKJJUNKNPTTO-AJFJRRQVBG;
	SMILES C1[C@@H]2[C@@H](C([C@H]3[C@@H](O2)Nc4c(c(=O)[nH]c(n4)N)N3)(O)O)OP(=O)(O1)O;
Properties
Chemical formula	C10H14N5O8P
Molar mass	363.223 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Cyclic pyranopterin monophosphate (cPMP) is an experimental treatment for molybdenum cofactor deficiency type A, which was developed by José Santamaría-Araujo and Guenter Schwarz at the German universities TU Braunschweig and the University of Cologne.[1][2]

cPMP is a precursor to molybdopterin, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase and aldehyde oxidase.[3]

References

Günter Schwarz; José Angel Santamaria-Araujo; Stefan Wolf; Heon-Jin Lee; Ibrahim M. Adham; Hermann-Josef Gröne; Herbert Schwegler; Jörn Oliver Sass; Tanja Otte; Petra Hänzelmann; Ralf R. Mendel; Wolfgang Engel; Jochen Reiss (2004). "Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli". Human Molecular Genetics. 13 (12): 1249–1255. doi:10.1093/hmg/ddh136. PMID 15115759.
Doctors risk untried drug to stop baby’s brain dissolving, TimesOnline, November 5, 2009
José Angel Santamaria-Araujo; Berthold Fischer; Tanja Otte; Manfred Nimtz; Ralf R. Mendel; Victor Wray; Günter Schwarz (2004). "The Tetrahydropyranopterin Structure of the Sulfur-free and Metal-free Molybdenum Cofactor Precursor". The Journal of Biological Chemistry. 279 (16): 15994–15999. doi:10.1074/jbc.M311815200. PMID 14761975.

External links

Guenter Schwarz Laboratory, Institute for Biochemistry - University of Cologne (English, German)

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[1] Günter Schwarz; José Angel Santamaria-Araujo; Stefan Wolf; Heon-Jin Lee; Ibrahim M. Adham; Hermann-Josef Gröne; Herbert Schwegler; Jörn Oliver Sass; Tanja Otte; Petra Hänzelmann; Ralf R. Mendel; Wolfgang Engel; Jochen Reiss (2004). "Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli". Human Molecular Genetics. 13 (12): 1249–1255. doi:10.1093/hmg/ddh136. PMID 15115759.

[2] Doctors risk untried drug to stop baby’s brain dissolving, TimesOnline, November 5, 2009

[3] José Angel Santamaria-Araujo; Berthold Fischer; Tanja Otte; Manfred Nimtz; Ralf R. Mendel; Victor Wray; Günter Schwarz (2004). "The Tetrahydropyranopterin Structure of the Sulfur-free and Metal-free Molybdenum Cofactor Precursor". The Journal of Biological Chemistry. 279 (16): 15994–15999. doi:10.1074/jbc.M311815200. PMID 14761975.