Cyclin O

CCNO
Identifiers
Aliases	CCNO, CCNU, CILD29, UDG2, Cyclin O
External IDs	OMIM: 607752 MGI: 2145534 HomoloGene: 50171 GeneCards: CCNO
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	55,233,608 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	112,990,777 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• uracil DNA N-glycosylase activity; • protein kinase activity; • cyclin-dependent protein serine/threonine kinase regulator activity; • protein kinase binding;
Cellular component	• cytoplasm; • cell nucleus; • cyclin-dependent protein kinase holoenzyme complex;
Biological process	• cell projection organization; • multi-ciliated epithelial cell differentiation; • response to drug; • cilium morphogenesis; • GO:0007067 mitotic cell cycle; • cell cycle; • cell division; • regulation of cyclin-dependent protein serine/threonine kinase activity; • protein phosphorylation; • regulation of mitotic nuclear division; • positive regulation of cell proliferation; • positive regulation of cell cycle; • mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologs
	10309
	218630
	ENSG00000152669
	ENSMUSG00000042417
	P22674
	P0C242
	NM_001024592; NM_021147
	NM_001081062
	NP_066970
	NP_001074531
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-O is a protein that in humans is encoded by the CCNO gene.[5]

Interactions

Cyclin O has been shown to interact with RPA2[6] and PCNA.[6][7]

References

GRCh38: Ensembl release 89: ENSG00000152669 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000042417 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: CCNO cyclin O".
Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE (July 1999). "Post-replicative base excision repair in replication foci". The EMBO Journal. 18 (13): 3834–44. doi:10.1093/emboj/18.13.3834. PMC 1171460. PMID 10393198.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (October 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.

Caradonna S, Muller-Weeks S (December 2001). "The nature of enzymes involved in uracil-DNA repair: isoform characteristics of proteins responsible for nuclear and mitochondrial genomic integrity". Current Protein & Peptide Science. 2 (4): 335–47. doi:10.2174/1389203013381044. PMID 12369930.
Muller SJ, Caradonna S (February 1991). "Isolation and characterization of a human cDNA encoding uracil-DNA glycosylase". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1088 (2): 197–207. doi:10.1016/0167-4781(91)90055-Q. PMID 2001396.
Muller SJ, Caradonna S (January 1993). "Cell cycle regulation of a human cyclin-like gene encoding uracil-DNA glycosylase". The Journal of Biological Chemistry. 268 (2): 1310–9. PMID 8419333.
Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE (July 1999). "Post-replicative base excision repair in replication foci". The EMBO Journal. 18 (13): 3834–44. doi:10.1093/emboj/18.13.3834. PMC 1171460. PMID 10393198.
Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles CJ, Edwards AM, Chazin WJ (October 2000). "Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA". Cell. 103 (3): 449–56. doi:10.1016/S0092-8674(00)00136-7. PMID 11081631. S2CID 16640087.
Kavli B, Sundheim O, Akbari M, Otterlei M, Nilsen H, Skorpen F, Aas PA, Hagen L, Krokan HE, Slupphaug G (October 2002). "hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup". The Journal of Biological Chemistry. 277 (42): 39926–36. doi:10.1074/jbc.M207107200. PMID 12161446.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (October 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Priet S, Navarro JM, Gros N, Quérat G, Sire J (March 2003). "Differential incorporation of uracil DNA glycosylase UNG2 into HIV-1, HIV-2, and SIV(MAC) viral particles". Virology. 307 (2): 283–9. doi:10.1016/S0042-6822(02)00073-9. PMID 12667798.
Elder RT, Zhu X, Priet S, Chen M, Yu M, Navarro JM, Sire J, Zhao Y (July 2003). "A fission yeast homologue of the human uracil-DNA-glycosylase and their roles in causing DNA damage after overexpression". Biochemical and Biophysical Research Communications. 306 (3): 693–700. doi:10.1016/S0006-291X(03)01036-2. PMID 12810074.
Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA (August 2004). "The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair". Molecular Cell. 15 (4): 621–34. doi:10.1016/j.molcel.2004.08.007. PMID 15327777.
Hirst R, Gosden R, Miller D (June 2006). "The cyclin-like uracil DNA glycosylase (UDG) of murine oocytes and its relationship to human and chimpanzee homologues". Gene. 375: 95–102. doi:10.1016/j.gene.2006.02.030. PMID 16697536.
Verma SC, Bajaj BG, Cai Q, Si H, Seelhammer T, Robertson ES (November 2006). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus recruits uracil DNA glycosylase 2 at the terminal repeats and is important for latent persistence of the virus". Journal of Virology. 80 (22): 11178–90. doi:10.1128/JVI.01334-06. PMC 1642147. PMID 16928741.
Yang B, Chen K, Zhang C, Huang S, Zhang H (April 2007). "Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA". The Journal of Biological Chemistry. 282 (16): 11667–75. doi:10.1074/jbc.M606864200. PMID 17272283.
Schröfelbauer B, Hakata Y, Landau NR (March 2007). "HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1". Proceedings of the National Academy of Sciences of the United States of America. 104 (10): 4130–5. doi:10.1073/pnas.0610167104. PMC 1820720. PMID 17360488.
Pettersen HS, Sundheim O, Gilljam KM, Slupphaug G, Krokan HE, Kavli B (2007). "Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms". Nucleic Acids Research. 35 (12): 3879–92. doi:10.1093/nar/gkm372. PMC 1919486. PMID 17537817.

External links

CCNO human gene location in the UCSC Genome Browser.
CCNO human gene details in the UCSC Genome Browser.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152669 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042417 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CCNO cyclin O".

[pmid10393198-6] Otterlei M, Warbrick E, Nagelhus TA, Haug T, Slupphaug G, Akbari M, Aas PA, Steinsbekk K, Bakke O, Krokan HE (July 1999). "Post-replicative base excision repair in replication foci". The EMBO Journal. 18 (13): 3834–44. doi:10.1093/emboj/18.13.3834. PMC 1171460. PMID 10393198.

[pmid12171929-7] Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (October 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.

Cyclin O

Interactions

References

Further reading

External links