DDX11

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.[5]

DDX11
Identifiers
Aliases	DDX11, CHL1, CHLR1, KRG2, WABS, DEAD/H-box helicase 11
External IDs	OMIM: 601150 MGI: 2443590 HomoloGene: 68973 GeneCards: DDX11
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p11.21 Start 31,073,860 bp[1] End 31,104,799 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 E1.1 Start 66,123,520 bp[2] End 66,152,174 bp[2]
Gene ontology Molecular function • 4 iron, 4 sulfur cluster binding • nucleotide binding • GO:0008026 helicase activity • iron-sulfur cluster binding • metal ion binding • single-stranded DNA binding • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • GO:0001948 protein binding • RNA binding • nucleic acid binding • double-stranded DNA binding • hydrolase activity • ATP binding • DNA binding • chromatin binding • DNA replication origin binding • single-stranded RNA binding • GO:0004003 DNA helicase activity • DNA-dependent ATPase activity • RNA-dependent ATPase activity • triplex DNA binding • G-quadruplex DNA binding Cellular component • nucleolus • nuclear chromatin • extracellular exosome • cell nucleus • spindle pole • fibrillar center • nucleoplasm • chromosome • cytoplasm • centrosome • microtubule organizing center • cytoskeleton • midbody • mitotic cohesin complex • Ctf18 RFC-like complex Biological process • sister chromatid cohesion • IRE1-mediated unfolded protein response • GO:0022415 viral process • nucleobase-containing compound metabolic process • DNA replication • DNA repair • transcription, DNA-templated • regulation of transcription, DNA-templated • cellular response to DNA damage stimulus • multicellular organism development • replication fork processing • positive regulation of endodeoxyribonuclease activity • negative regulation of protein binding • DNA duplex unwinding • positive regulation of chromatin binding • G-quadruplex DNA unwinding • positive regulation of sister chromatid cohesion • cellular response to hydroxyurea • cellular response to cisplatin • positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter • cellular response to bleomycin • nucleolar chromatin organization • positive regulation of double-strand break repair • establishment of sister chromatid cohesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1663	320209
Ensembl	ENSG00000013573	ENSMUSG00000035842
UniProt	Q96FC9	Q6AXC6
RefSeq (mRNA)	NM_001257144 NM_001257145 NM_004399 NM_030653 NM_030655 NM_152438	NM_001003919 NM_001348292
RefSeq (protein)	NP_001244073 NP_001244074 NP_004390 NP_085911 NP_689651	NP_001003919 NP_001335221
Location (UCSC)	Chr 12: 31.07 – 31.1 Mb	Chr 17: 66.12 – 66.15 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[5]