DDX39

ATP-dependent RNA helicase DDX39 is an enzyme that in humans is encoded by the DDX39 gene.[5][6]

DDX39A
Identifiers
AliasesDDX39A, BAT1, BAT1L, DDX39, DDXL, URH49, DEAD-box helicase 39A, DExD-box helicase 39A
External IDsMGI: 1915528 HomoloGene: 68487 GeneCards: DDX39A
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19p13.12Start14,408,798 bp[1]
End14,419,383 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

10212

68278

Ensembl

ENSG00000123136

ENSMUSG00000005481

UniProt

O00148

Q8VDW0

RefSeq (mRNA)

NM_001204057
NM_005804
NM_138998

NM_197982
NM_001363116
NM_001363117

RefSeq (protein)

NP_005795

NP_932099
NP_001350045
NP_001350046

Location (UCSC)Chr 19: 14.41 – 14.42 MbChr 8: 83.72 – 83.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000123136 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000005481 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Peelman LJ, Chardon P, Nunes M, Renard C, Geffrotin C, Vaiman M, Van Zeveren A, Coppieters W, van de Weghe A, Bouquet Y, et al. (Aug 1995). "The BAT1 gene in the MHC encodes an evolutionarily conserved putative nuclear RNA helicase of the DEAD family". Genomics. 26 (2): 210–8. doi:10.1016/0888-7543(95)80203-X. PMID 7601445.
  6. "Entrez Gene: DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39".

Further reading


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