DEDD

Death effector domain containing protein is a protein that in humans is encoded by the DEDD gene.[5][6][7]

DEDD
Identifiers
AliasesDEDD, CASP8IP1, DEDD1, DEFT, FLDED1, KE05, death effector domain containing
External IDsOMIM: 606841 MGI: 1333874 HomoloGene: 7980 GeneCards: DEDD
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.3Start161,120,974 bp[1]
End161,132,688 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9191

21945

Ensembl

ENSG00000158796

ENSMUSG00000013973

UniProt

O75618

Q9Z1L3

RefSeq (mRNA)

NM_001039711
NM_001039712
NM_004216
NM_032998
NM_001330765

RefSeq (protein)

NP_001034800
NP_001034801
NP_001317694
NP_127491

Location (UCSC)Chr 1: 161.12 – 161.13 MbChr 1: 171.33 – 171.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that contains a death effector domain (DED). DED is a protein–protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.[7]

Interactions

DEDD has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000158796 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000013973 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Dec 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus". EMBO J. 17 (20): 5974–86. doi:10.1093/emboj/17.20.5974. PMC 1170924. PMID 9774341.
  6. Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ (Dec 1998). "DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells". Endocrinology. 139 (12): 4839–48. doi:10.1210/en.139.12.4839. PMID 9832420.
  7. "Entrez Gene: DEDD death effector domain containing".
  8. Zhan Y, Hegde R, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES (Apr 2002). "Death effector domain-containing proteins DEDD and FLAME-3 form nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC". Cell Death Differ. 9 (4): 439–47. doi:10.1038/sj.cdd.4401038. PMID 11965497.
  9. Roth W, Stenner-Liewen F, Pawlowski K, Godzik A, Reed JC (Mar 2002). "Identification and characterization of DEDD2, a death effector domain-containing protein". J. Biol. Chem. 277 (9): 7501–8. doi:10.1074/jbc.M110749200. PMID 11741985.
  10. Stegh AH, Schickling O, Ehret A, Scaffidi C, Peterhänsel C, Hofmann TG, Grummt I, Krammer PH, Peter ME (Oct 1998). "DEDD, a novel death effector domain-containing protein, targeted to the nucleolus". EMBO J. 17 (20): 5974–86. doi:10.1093/emboj/17.20.5974. PMC 1170924. PMID 9774341.
  11. Alcivar A, Hu S, Tang J, Yang X (Jan 2003). "DEDD and DEDD2 associate with caspase-8/10 and signal cell death". Oncogene. 22 (2): 291–7. doi:10.1038/sj.onc.1206099. PMID 12527898.

Further reading


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