DKK2

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene.[5][6]

DKK2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDKK2, DKK-2, dickkopf WNT signaling pathway inhibitor 2
External IDsOMIM: 605415 MGI: 1890663 HomoloGene: 8681 GeneCards: DKK2
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q25Start106,921,802 bp[1]
End107,283,806 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

27123

56811

Ensembl

ENSG00000155011

ENSMUSG00000028031

UniProt

Q9UBU2

Q9QYZ8

RefSeq (mRNA)

NM_014421

NM_020265

RefSeq (protein)

NP_055236

NP_064661

Location (UCSC)Chr 4: 106.92 – 107.28 MbChr 3: 132.09 – 132.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.

It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000155011 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028031 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Krupnik VE, Sharp JD, Jiang C, Robison K, Chickering TW, Amaravadi L, et al. (October 1999). "Functional and structural diversity of the human Dickkopf gene family". Gene. 238 (2): 301–13. doi:10.1016/S0378-1119(99)00365-0. PMID 10570958.
  6. "Entrez Gene: DKK2 dickkopf homolog 2 (Xenopus laevis)".
  7. Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, et al. (December 2018). "Regional Control of Hairless versus Hair-Bearing Skin by Dkk2". Cell Reports. 25 (11): 2981–2991.e3. doi:10.1016/j.celrep.2018.11.017. PMC 6345517. PMID 30509557.

Further reading

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.