DVL2

Segment polarity protein dishevelled homolog DVL-2 is a protein that in humans is encoded by the DVL2 gene.[5][6]

DVL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDVL2, dishevelled segment polarity protein 2
External IDsOMIM: 602151 MGI: 106613 HomoloGene: 20927 GeneCards: DVL2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17p13.1Start7,225,342 bp[1]
End7,234,517 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

1856

13543

Ensembl

ENSG00000004975

ENSMUSG00000020888

UniProt

O14641

Q60838

RefSeq (mRNA)

NM_004422

NM_007888

RefSeq (protein)

NP_004413

NP_031914

Location (UCSC)Chr 17: 7.23 – 7.23 MbChr 11: 70 – 70.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans.[6]

Interactions

DVL2 has been shown to interact with Zinc finger protein 165,[7] DAB2[8] and Arrestin beta 1.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000004975 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020888 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Greco TL, Sussman DJ, Camper SA (January 1997). "Dishevelled-2 maps to human chromosome 17 and distal to Wnt3a and vestigial tail (vt) on mouse chromosome 11". Mamm Genome. 7 (6): 475–6. doi:10.1007/s003359900144. PMID 8662242. S2CID 39619679.
  6. "Entrez Gene: DVL2 dishevelled, dsh homolog 2 (Drosophila)".
  7. Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  8. Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12): 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222.
  9. Chen, W; Hu L A; Semenov M V; Yanagawa S; Kikuchi A; Lefkowitz R J; Miller W E (December 2001). "β-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 14889–94. Bibcode:2001PNAS...9814889C. doi:10.1073/pnas.211572798. ISSN 0027-8424. PMC 64954. PMID 11742073.

Further reading


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