DYNLL2

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.[5][6]

DYNLL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDYNLL2, DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDsOMIM: 608942 MGI: 1915347 HomoloGene: 115597 GeneCards: DYNLL2
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q22Start58,083,419 bp[1]
End58,095,542 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

140735

68097

Ensembl

ENSG00000264364

ENSMUSG00000020483

UniProt

Q96FJ2

Q9D0M5

RefSeq (mRNA)

NM_080677

NM_001168471
NM_001168472
NM_026556

RefSeq (protein)

NP_542408

NP_001161943
NP_001161944
NP_080832

Location (UCSC)Chr 17: 58.08 – 58.1 MbChr 11: 87.98 – 87.99 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions

DYNLL2 has been shown to interact with DLG4,[7] C12orf40,[8] DLGAP1,[7] MYO5A[7][9] and BMF.[9][10]

References

  1. GRCh38: Ensembl release 89: ENSG00000264364 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020483 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  6. "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
  7. Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. UNITED STATES. 20 (12): 4524–34. doi:10.1523/JNEUROSCI.20-12-04524.2000. ISSN 0270-6474. PMC 6772433. PMID 10844022.
  8. Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
  9. Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. United States. 293 (5536): 1829–32. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872. S2CID 5638023.
  10. Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

Further reading

  • Overview of all the structural information available in the PDB for UniProt: Q96FJ2 (Dynein light chain 2, cytoplasmic) at the PDBe-KB.


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