David Tuveson

David Tuveson received a B.S. in chemistry from the Massachusetts Institute of Technology in 1987. He received an M.D.-Ph.D. from the Johns Hopkins School of Medicine in 1994, where his Ph.D. adviser was Douglas Fearon. He completed a residency at Brigham and Women's Hospital from 1994-1997. From 1997-2000, he pursued a Fellowship in Hematology and Oncology at the Dana–Farber Cancer Institute. During this time, he also performed postdoctoral research in mouse models of lung cancer in the laboratory of Tyler Jacks at the Massachusetts Institute of Technology.[4]

Following completion of his fellowship training, Tuveson started his own laboratory at the University of Pennsylvania, where he was Assistant Professor of Medicine from 2002-2006.[5] In 2006, he moved to the Cambridge Research Institute, where he was a Senior Group Leader and a Professor of Pancreatic Cancer Medicine. In 2012, he took a position as a group leader and The Deputy Director of the Cancer Center at Cold Spring Harbor Laboratory.[5] He is a member of the Editorial Board for Oncogene.[6]

During his postdoctoral training in the Jacks Laboratory, Tuveson learned how to engineer mouse models to study human cancer.[5] During this time, he also studied gastrointestinal stromal tumors (GISTs), and worked with Dr. George Demetri to develop imatinib as a treatment for GIST.[7] When he started his own laboratory at the University of Pennsylvania, Tuveson developed some of the first genetically engineered mouse models to aid in the study of pancreatic cancer.[8][9][10] Using these mice, Tuveson has made several important discoveries in the biology of pancreatic cancer, including the work that contributed to the idea that the stromal cells of pancreatic tumors act as a barrier for therapies.[11] He later partnered with Hans Clevers to develop pancreatic cancer organoids – tumor cells taken from a human patient and cultured in the laboratory as three-dimensional spheres.[12] He is working with the National Cancer Institute to develop organoids for use in personalized medicine approaches to treating cancer.[13]

David Tuveson was given an AACR-PanCAN Career Development Award in Pancreatic Cancer research in 2003. He was also the recipient of an M.L. Smith Award in 2003 and a Rita Allen Foundation Scholar Award in 2004. He has also received a Distinguished Scholar Award from the Lustgarten Foundation.[14]

Tuveson has more than 100 publications, and has been cited more than 15,000 times. Some of his most important publications are:

• Johnson, L., Mercer, K., Greenbaum, D., Bronson, R.T., Crowley, D., Tuveson, D.A., Jacks, T. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature. 410:1111-1116 (2001)
• Demetri, G.D., von Mehren, M., Blanke, C.D., Van den Abbeele, A.D., Eisenberg, B., Roberts, P.J., Heinrich, M.C., Tuveson, D.A., Singer, S., Janicek, M., Fletcher, J.A., Silverman, S.G., Silberman, S.L., Capdeville, R., Kiese, B., Peng, B., Dimitrijevic, S., Druker, B.J., Corless, C., Fletcher, C.D.M., and Joensuu, H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. New England Journal of Medicine. 347:472-480 (2002)
• Hingorani, S.R., Petricoin, E.F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M.A., Ross, S., Conrads, T.P., Veenstra, T.D., Hitt, B.A., Kawaguchi, Y., Johann, D., Liotta, L.A., Crawford, H.C., Putt, M.E., Jacks, T., Wright, C.V., Hruban, R.H., Lowy, A.M., Tuveson, D.A. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4:437-450 (2003)
• Hingorani, S.R., Wang, L., Multani, A.S., Combs, C., Deramaudt, T.B., Hruban, R.H., Rustgi, A.K., Chang, S., Tuveson, D.A. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell. 7:469-483 (2005)
• Olive, K.P., Jacobetz, M.A., Davidson, C.J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M.A., Caldwell, M.E., Allard, D., Frese, K.K., Denicola, G., Feig, C., Combs, C., Winter, S.P., Ireland-Zecchini, H., Reichelt, S., Howat, W.J., Chang, A., Dhara, M., Wang, L., Rückert, F., Grützmann, R., Pilarsky, C., Izeradjene, K., Hingorani, S.R., Huang, P., Davies, S.E., Plunkett, W., Egorin, M., Hruban, R.H., Whitebread, N., McGovern, K., Adams, J., Iacobuzio-Donahue, C., Griffiths, J., Tuveson, D.A. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science. 324:1457-1461 (2009)
• DeNicola, G.M., Karreth, F.A., Humpton, T.J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K.H., Yeo, C.J., Calhoun, E.S., Scrimieri, F., Winter, J.M., Hruban, R.H., Iacobuzio-Donahue, C., Kern, S.E., Blair, I.A., Tuveson, D.A. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 475:106-109 (2011)
• Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban, R.H., Offerhaus, G.J., Vries, R.G., Clevers, H., Tuveson, D.A. Organoid models of human and mouse ductal pancreatic cancer. Cell. 160:324-338 (2015)

• The Tuveson Laboratory Website