Deoxyribonuclease ii, lysosomal

DNASE2
Identifiers
Aliases	DNASE2, DNASE2A, DNL, DNL2, deoxyribonuclease II, lysosomal, deoxyribonuclease 2, lysosomal
External IDs	OMIM: 126350 MGI: 1329019 HomoloGene: 68179 GeneCards: DNASE2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	12,881,466 bp[1]
Gene ontology
Molecular function	• DNA binding; • nuclease activity; • endonuclease activity; • endodeoxyribonuclease activity; • hydrolase activity; • deoxyribonuclease II activity;
Cellular component	• lysosome; • extracellular exosome; • intracellular;
Biological process	• erythrocyte differentiation; • multicellular organism development; • DNA metabolic process; • DNA catabolic process; • DNA catabolic process, endonucleolytic; • apoptotic process; • apoptotic DNA fragmentation; • regulation of immune response;
	Sources:Amigo / QuickGO
Orthologs
	1777
	13423
	ENSG00000105612
	ENSMUSG00000003812
	O00115
	P56542
	NM_001375
	NM_010062; NM_001368295; NM_001368296
	NP_001366; NP_001366.1
	NP_034192; NP_001355224; NP_001355225
	Wikidata
View/Edit Human	View/Edit Mouse

Deoxyribonuclease II, lysosomal is a protein that in humans is encoded by the DNASE2 gene. [4]

Function

This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis.

Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.

References

GRCh38: Ensembl release 89: ENSG00000105612 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Deoxyribonuclease II, lysosomal". Retrieved 2016-09-07.

Deoxyribonuclease ii, lysosomal

Function

References

Further reading