Derlin-2

DERL2
Identifiers
Aliases	DERL2, F-LAN-1, F-LANa, FLANa, CGI-101, DERtrin-2, derlin 2, derlin-2
External IDs	OMIM: 610304 MGI: 2151483 HomoloGene: 9356 GeneCards: DERL2
Gene location (Human)
Chr.	Chromosome 17 (human)[1]
End	5,486,811 bp[1]
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)[2]
End	71,019,841 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • serine-type endopeptidase activity;
Cellular component	• integral component of membrane; • integral component of endoplasmic reticulum membrane; • late endosome; • early endosome; • endoplasmic reticulum membrane; • endoplasmic reticulum; • membrane; • endoplasmic reticulum quality control compartment; • signal recognition particle receptor complex; • signal recognition particle;
Biological process	• endoplasmic reticulum unfolded protein response; • positive regulation of cell growth; • retrograde protein transport, ER to cytosol; • response to unfolded protein; • negative regulation of retrograde protein transport, ER to cytosol; • positive regulation of cell proliferation; • ubiquitin-dependent ERAD pathway; • suckling behavior; • endoplasmic reticulum mannose trimming; • proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	51009
	116891
	ENSG00000072849
	ENSMUSG00000018442
	Q9GZP9
	Q8BNI4
	NM_001304777; NM_001304779; NM_016041
	NM_001291146; NM_001291147; NM_001291148; NM_033562
	NP_001291706; NP_001291708; NP_057125
	NP_001278075; NP_001278076; NP_001278077; NP_291040
	Wikidata
View/Edit Human	View/Edit Mouse

Derlin-2 is a protein that in humans is encoded by the DERL2 gene.[5][6][7]

References

GRCh38: Ensembl release 89: ENSG00000072849 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000018442 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Ying H, Yu Y, Xu Y (Aug 2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer". Biochem Biophys Res Commun. 286 (2): 394–400. doi:10.1006/bbrc.2001.5390. PMID 11500051.
"Entrez Gene: DERL2 Der1-like domain family, member 2".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lilley BN, Ploegh HL (2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lilley BN, Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–301. doi:10.1073/pnas.0505014102. PMC 1242303. PMID 16186509.
Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
Rhee S, Grinnell F (2006). "P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts". J. Cell Biol. 172 (3): 423–32. doi:10.1083/jcb.200505175. PMC 2063651. PMID 16449192.
Maas C, Tagnaouti N, Loebrich S, et al. (2006). "Neuronal cotransport of glycine receptor and the scaffold protein gephyrin". J. Cell Biol. 172 (3): 441–51. doi:10.1083/jcb.200506066. PMC 2063653. PMID 16449194.
Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL (2006). "Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection". J. Virol. 80 (17): 8739–44. doi:10.1128/JVI.00791-06. PMC 1563856. PMID 16912321.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000072849 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018442 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10810093-5] Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.

[pmid11500051-6] Ying H, Yu Y, Xu Y (Aug 2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer". Biochem Biophys Res Commun. 286 (2): 394–400. doi:10.1006/bbrc.2001.5390. PMID 11500051.

[entrez-7] "Entrez Gene: DERL2 Der1-like domain family, member 2".

Derlin-2

See also

References

Further reading