Dermatan 4-sulfotransferase
Dermatan 4-sulfotransferase (EC 2.8.2.35, dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase, dermatan-4-sulfotransferase-1, dermatan-4-sulfotransferase 1, D4ST-1, dermatan N-acetylgalactosamine 4-O-sulfotransferase, CHST14 protein, CHST14) is an enzyme with systematic name 3'-phospho-5'-adenylyl sulfate:(dermatan)-N-acetyl-D-galactosamine 4-sulfotransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- 3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
| Dermatan 4-sulfotransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.2.35 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan.
References
- Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU (September 2001). "Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase". The Journal of Biological Chemistry. 276 (39): 36344–53. doi:10.1074/jbc.M105848200. PMID 11470797.
- Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (September 2003). "Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis". The Journal of Biological Chemistry. 278 (38): 36115–27. doi:10.1074/jbc.M306044200. PMID 12847091.
- Pacheco B, Maccarana M, Malmström A (November 2009). "Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate". Glycobiology. 19 (11): 1197–203. doi:10.1093/glycob/cwp110. PMID 19661164.
- Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K (July 2006). "Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases". The Journal of Biological Chemistry. 281 (28): 18942–52. doi:10.1074/jbc.M510870200. PMID 16702220.
External links
- Dermatan+4-sulfotransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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