Dextran 70

Dextran 70 is a type of fluid given by injection into a vein to expand blood volume.[1] Specifically it is used for shock such as that caused by bleeding or burns when blood transfusions are not quickly available.[2] However, it does not carry oxygen.[2]

Dextran 70
Clinical data
Trade namesRescueFlow, others
AHFS/Drugs.comMonograph
Routes of
administration
intravenous
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
UNII
Chemical and physical data
Molar mass70,000 Da

Common side effects include vomiting, fever, and joint pains.[2] Other side effects include allergic reactions and poor blood clotting.[1] It is not recommended in people with kidney failure, significant heart failure, or a clotting disorder.[2] It is not recommended during pregnancy.[3] It works by pulling fluid from the extravascular space into the blood vessels.[2]

Dextran 70 was approved for medical use in 1947.[4] It is on the World Health Organization's List of Essential Medicines.[5] It comes in either sodium chloride solution or glucose solution.[2]

References

  1. World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 248, 257–58, 279, 287. hdl:10665/44053. ISBN 9789241547659.
  2. "Dextran 70". The American Society of Health-System Pharmacists. Archived from the original on 3 January 2017. Retrieved 8 December 2016.
  3. British national formulary : BNF 69 (69 ed.). British Medical Association. 2015. p. 686. ISBN 9780857111562.
  4. BeMiller, James N.; Whistler, Roy L. (2012). Industrial Gums: Polysaccharides and Their Derivatives (3 ed.). Academic Press. p. 411. ISBN 9780080926544. Archived from the original on 2017-01-03.
  5. World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  • "Dextran 70". Drug Information Portal. U.S. National Library of Medicine.
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