EDF1

Endothelial differentiation-related factor 1 is a protein that in humans is encoded by the EDF1 gene.[5][6][7]

EDF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEDF1, EDF-1, MBF1, CFAP280, endothelial differentiation related factor 1
External IDsOMIM: 605107 MGI: 1891227 HomoloGene: 2809 GeneCards: EDF1
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q34.3Start136,862,119 bp[1]
End136,866,308 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8721

59022

Ensembl

ENSG00000107223

ENSMUSG00000015092

UniProt

O60869

Q9JMG1

RefSeq (mRNA)

NM_153200
NM_001281297
NM_001281298
NM_001281299
NM_003792

NM_021519

RefSeq (protein)

NP_001268226
NP_001268227
NP_001268228
NP_003783
NP_694880

NP_067494

Location (UCSC)Chr 9: 136.86 – 136.87 MbChr 2: 25.56 – 25.56 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene.[7]

Interactions

EDF1 has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000107223 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000015092 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Dragoni I, Mariotti M, Consalez GG, Soria MR, Maier JA (December 1998). "EDF-1, a novel gene product down-regulated in human endothelial cell differentiation". J Biol Chem. 273 (47): 31119–24. doi:10.1074/jbc.273.47.31119. PMID 9813014.
  6. Ballabio E, Mariotti M, De Benedictis L, Maier JA (April 2004). "The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A". Cell Mol Life Sci. 61 (9): 1069–74. doi:10.1007/s00018-004-4016-0. PMID 15112053. S2CID 861006.
  7. "Entrez Gene: EDF1 endothelial differentiation-related factor 1".
  8. Brendel C, Gelman L, Auwerx J (June 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Mol. Endocrinol. 16 (6): 1367–77. doi:10.1210/mend.16.6.0843. PMID 12040021.
  9. Mariotti M, De Benedictis L, Avon E, Maier JA (August 2000). "Interaction between endothelial differentiation-related factor-1 and calmodulin in vitro and in vivo". J. Biol. Chem. 275 (31): 24047–51. doi:10.1074/jbc.M001928200. PMID 10816571.
  10. Kabe Y, Goto M, Shima D, Imai T, Wada T, Morohashi Ki, Shirakawa M, Hirose S, Handa H (November 1999). "The role of human MBF1 as a transcriptional coactivator". J. Biol. Chem. 274 (48): 34196–202. doi:10.1074/jbc.274.48.34196. PMID 10567391.

Further reading


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