ENSA (gene)

ENSA
Identifiers
Aliases	ENSA, ARPP-19e, endosulfine alpha
External IDs	OMIM: 603061 MGI: 1891189 HomoloGene: 37924 GeneCards: ENSA
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	150,629,612 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	95,632,102 bp[2]
RNA expression pattern
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	• protein phosphatase 2A binding; • potassium channel inhibitor activity; • receptor binding; • GO:0001948 protein binding; • ion channel inhibitor activity; • phosphatase inhibitor activity; • protein phosphatase inhibitor activity; • protein phosphatase regulator activity;
Cellular component	• nucleoplasm; • cytoplasm;
Biological process	• cell division; • cell cycle; • G2/M transition of mitotic cell cycle; • response to glucose; • response to nutrient; • regulation of insulin secretion; • GO:0048553 negative regulation of catalytic activity; • negative regulation of protein dephosphorylation; • GO:0007067 mitotic cell cycle; • negative regulation of phosphoprotein phosphatase activity; • regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	2029
	56205
	ENSG00000143420
	ENSMUSG00000038619
	O43768
	P60840
NM_207168; NM_004436; NM_207042; NM_207043; NM_207044;
	NM_207045; NM_207046; NM_207047
	NM_001026212; NM_019561
NP_004427; NP_996925; NP_996926; NP_996927; NP_996928;
	NP_996929; NP_996930; NP_997051
	NP_001021383; NP_062507
	Wikidata
View/Edit Human	View/Edit Mouse

Alpha-endosulfine is a protein that in humans is encoded by the ENSA gene.[5][6]

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]

References

GRCh38: Ensembl release 89: ENSG00000143420 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000038619 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (Aug 1998). "Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties". Proc Natl Acad Sci U S A. 95 (14): 8387–91. Bibcode:1998PNAS...95.8387H. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.
"Entrez Gene: ENSA endosulfine alpha".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Héron L, Virsolvy A, Apiou F, et al. (1999). "Isolation, characterization, and chromosomal localization of the human ENSA gene that encodes alpha-endosulfine, a regulator of beta-cell K(ATP) channels". Diabetes. 48 (9): 1873–6. doi:10.2337/diabetes.48.9.1873. PMID 10480622.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Kim SH, Lubec G (2002). "Decreased alpha-endosulfine, an endogenous regulator of ATP-sensitive potassium channels, in brains from adult Down syndrome patients". J. Neural Transm. Suppl. (61): 1–9. doi:10.1007/978-3-7091-6262-0_1. ISBN 978-3-211-83704-7. PMID 11771735.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bataille D (2003). "Endosulfines: Novel regulators of insulin secretion". Drug News Perspect. 13 (8): 453–62. PMID 12937617.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Wang H, Craig RL, Schay J, et al. (2004). "Alpha-endosulfine, a positional and functional candidate gene for type 2 diabetes: molecular screening, association studies, and role in reduced insulin secretion". Mol. Genet. Metab. 81 (1): 9–15. doi:10.1016/j.ymgme.2003.08.003. PMID 14728986.
Thameem F, Farook VS, Yang X, et al. (2004). "The transcribed endosulfine alpha gene is located within a type 2 diabetes-linked region on 1q: sequence and expression analysis in Pima Indians". Mol. Genet. Metab. 81 (1): 16–21. doi:10.1016/j.ymgme.2003.09.013. PMID 14728987.
Gabrielsson BG, Karlsson AC, Lönn M, et al. (2004). "Molecular characterization of a local sulfonylurea system in human adipose tissue". Mol. Cell. Biochem. 258 (1–2): 65–71. doi:10.1023/B:MCBI.0000012837.11847.c8. PMID 15030171. S2CID 22988098.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143420 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038619 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9653196-5] Heron L, Virsolvy A, Peyrollier K, Gribble FM, Le Cam A, Ashcroft FM, Bataille D (Aug 1998). "Human α-endosulfine, a possible regulator of sulfonylurea-sensitive KATP channel: Molecular cloning, expression and biological properties". Proc Natl Acad Sci U S A. 95 (14): 8387–91. Bibcode:1998PNAS...95.8387H. doi:10.1073/pnas.95.14.8387. PMC 20985. PMID 9653196.

[entrez-6] "Entrez Gene: ENSA endosulfine alpha".

ENSA (gene)

References

Further reading