EPS8L2

EPS8L2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWU, 1WXB
Identifiers
Aliases	EPS8L2, EPS8R2, EPS8 like 2, DFNB106
External IDs	OMIM: 614988 MGI: 2138828 HomoloGene: 69358 GeneCards: EPS8L2
Gene location (Human)
Chr.	Chromosome 11 (human)[1]
End	727,727 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	141,363,020 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• Rac guanyl-nucleotide exchange factor activity; • Rho guanyl-nucleotide exchange factor activity; • actin binding; • cadherin binding; • GO:0001948 protein binding;
Cellular component	• ruffle membrane; • vesicle; • cell membrane; • extracellular exosome; • cytoplasm; • cytosol; • stereocilium bundle; • stereocilium tip; • stereocilium; • macromolecular complex; • cell projection;
Biological process	• regulation of Rho protein signal transduction; • Rho protein signal transduction; • positive regulation of ruffle assembly; • sensory perception of sound; • regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	64787
	98845
	ENSG00000177106
	ENSMUSG00000025504
	Q9H6S3
	Q99K30
	NM_022772
	NM_133191
	NP_073609
	NP_573454
	Wikidata
View/Edit Human	View/Edit Mouse

Epidermal growth factor receptor kinase substrate 8-like protein 2 is an enzyme that in humans is encoded by the EPS8L2 gene.[5][6]

This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown.[6]

References

GRCh38: Ensembl release 89: ENSG00000177106 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000025504 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.
"Entrez Gene: EPS8L2 EPS8-like 2".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Offenhäuser N, Borgonovo A, Disanza A, et al. (2004). "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway". Mol. Biol. Cell. 15 (1): 91–8. doi:10.1091/mbc.E03-06-0427. PMC 307530. PMID 14565974.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177106 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025504 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12620401-5] Tocchetti A, Confalonieri S, Scita G, Di Fiore PP, Betsholtz C (Mar 2003). "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure". Genomics. 81 (2): 234–44. doi:10.1016/S0888-7543(03)00002-8. PMID 12620401.

[entrez-6] "Entrez Gene: EPS8L2 EPS8-like 2".

EPS8L2

References

Further reading