EXOC1

Exocyst complex component 1 is a protein that in humans is encoded by the EXOC1 gene.[5][6][7]

EXOC1
Identifiers
AliasesEXOC1, BM-102, SEC3, SEC3L1, SEC3P, exocyst complex component 1
External IDsOMIM: 607879 MGI: 2445020 HomoloGene: 41241 GeneCards: EXOC1
Gene location (Human)
Chr.Chromosome 4 (human)[1]
Band4q12Start55,853,648 bp[1]
End55,905,086 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

55763

69940

Ensembl

ENSG00000090989

ENSMUSG00000036435

UniProt

Q9NV70

Q8R3S6

RefSeq (mRNA)

NM_001024924
NM_018261
NM_178237

RefSeq (protein)

NP_001020095
NP_060731
NP_839955

Location (UCSC)Chr 4: 55.85 – 55.91 MbChr 5: 76.53 – 76.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. Alternatively spliced transcript variants encoding distinct isoforms have been described.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000090989 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000036435 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
  6. Brymora A, Valova VA, Larsen MR, Roufogalis BD, Robinson PJ (Aug 2001). "The brain exocyst complex interacts with RalA in a GTP-dependent manner: identification of a novel mammalian Sec3 gene and a second Sec15 gene". J Biol Chem. 276 (32): 29792–7. doi:10.1074/jbc.C100320200. PMID 11406615.
  7. "Entrez Gene: EXOC1 exocyst complex component 1".

Further reading


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