EXOC3

Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.[5][6]

EXOC3
Identifiers
AliasesEXOC3, SEC6, SEC6L1, Sec6p, exocyst complex component 3
External IDsOMIM: 608186 MGI: 2443972 HomoloGene: 38296 GeneCards: EXOC3
Gene location (Human)
Chr.Chromosome 5 (human)[1]
Band5p15.33Start443,175 bp[1]
End471,937 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

11336

211446

Ensembl

ENSG00000180104

ENSMUSG00000034152

UniProt

O60645

Q6KAR6

RefSeq (mRNA)

NM_007277

NM_177333

RefSeq (protein)

NP_009208

NP_796307

Location (UCSC)Chr 5: 0.44 – 0.47 MbChr 13: 74.17 – 74.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity.[6]

Interactions

EXOC3 has been shown to interact with DLG3[7] and EXOC4.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000180104 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000034152 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  6. "Entrez Gene: EXOC3 exocyst complex component 3".
  7. Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (Jun 2003). "NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex". Nat. Cell Biol. 5 (6): 520–30. doi:10.1038/ncb990. PMID 12738960. S2CID 13444388.
  8. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (Apr 2003). "The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin". Nature. 422 (6932): 629–33. doi:10.1038/nature01533. hdl:2027.42/62982. PMID 12687004. S2CID 4395760.

Further reading


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