Ecto-nox disulfide-thiol exchanger 1

ENOX1
Identifiers
Aliases	ENOX1, CNOX, PIG38, bA64J21.1, cCNOX, ecto-NOX disulfide-thiol exchanger 1
External IDs	OMIM: 610914 MGI: 2444896 HomoloGene: 56793 GeneCards: ENOX1
Gene location (Human)
Chr.	Chromosome 13 (human)[1]
End	43,786,908 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	77,721,760 bp[2]
Gene ontology
Molecular function	• oxidoreductase activity; • GO:0001948 protein binding; • nucleic acid binding;
Cellular component	• extracellular region; • membrane; • extracellular; • cell membrane; • external side of plasma membrane;
Biological process	• oxidation-reduction process; • rhythmic process; • Ultradian;
	Sources:Amigo / QuickGO
Orthologs
	55068
	239188
	ENSG00000120658
	ENSMUSG00000022012
	Q8TC92
	Q8BHR2
NM_001127615; NM_001242863; NM_017993; NM_001347963; NM_001347964;
	NM_001347965; NM_001347966; NM_001347967; NM_001347968; NM_001347969; NM_001347970; NM_001347971
	NM_001253759; NM_172813
NP_001121087; NP_001229792; NP_060463; NP_001334892; NP_001334893;
	NP_001334894; NP_001334895; NP_001334896; NP_001334897; NP_001334898; NP_001334899; NP_001334900
	NP_001240688; NP_766401
	Wikidata
View/Edit Human	View/Edit Mouse

Ecto-NOX disulfide-thiol exchanger 1 is a protein that in humans is encoded by the ENOX1 gene. [5]

Function

Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defense, intracellular redox homeostasis, and control of cell growth and survival. Members of the ecto-NOX family, such as CNOX, or ENOX1, are involved in plasma membrane transport pathways. These enzymes exhibit both a hydroquinone (NADH) oxidase activity and a protein disulfide-thiol interchange activity in series, with each activity cycling every 22 to 26 minutes (Scarlett et al., 2005 [PubMed 15882838]).

References

GRCh38: Ensembl release 89: ENSG00000120658 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000022012 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ecto-NOX disulfide-thiol exchanger 1". Retrieved 2017-02-17.

Jiang Z, Gorenstein NM, Morré DM, Morré DJ (2008). "Molecular cloning and characterization of a candidate human growth-related and time-keeping constitutive cell surface hydroquinone (NADH) oxidase". Biochemistry. 47 (52): 14028–38. doi:10.1021/bi801073p. PMID 19055324.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Landouré G, Knight MA, Stanescu H, Taye AA, Shi Y, Diallo O, Johnson JO, Hernandez D, Traynor BJ, Biesecker LG, Elkahloun A, Rinaldi C, Vincent A, Willcox N, Kleta R, Fischbeck KH, Burnett BG (2012). "A candidate gene for autoimmune myasthenia gravis". Neurology. 79 (4): 342–7. doi:10.1212/WNL.0b013e318260cbd0. PMC 3400092. PMID 22744667.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000120658 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022012 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ecto-NOX disulfide-thiol exchanger 1". Retrieved 2017-02-17.

Ecto-nox disulfide-thiol exchanger 1

Function

See also

References

Further reading