Enterobacteria greA leader

The Enterobacteria greA leader is a putative attenuator element identified by bioinformatics within bacteria of the γ-proteobacterial Enterobacteriales order.[1] It is located upstream of the rnk gene, encoding a transcription elongation factor, and presents a Rho-independent terminator at the 3' end. This RNA is presumed to operate as a non-coding leader, which regulatory mechanism remains to be elucidated.[1] The short abortive form of the greA transcript may also play a role as an independent sRNA: Potrykus et al. have shown that its overexpression leads to the repression of several genes.[2] The motif might be related to other rnk leaders such as the Pseudomonas rnk leader and the Enterobacteria rnk leader.[1]

Enterobacteria greA leader
Conserved secondary structure of greA leader, colours represent the fraction of canonical base pairs
Identifiers
SymbolgreA_leader
RfamRF01769
Other data
RNA typeCis-reg; leader
Domain(s)Enterobacteriales
PDB structuresPDBe

See also

References
  1. Naville M, Gautheret D (2010). "Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuation". Genome Biology. 11 (9): R97. doi:10.1186/gb-2010-11-9-r97. PMC 2965389. PMID 20920266.
  2. Potrykus K, Murphy H, Chen X, Epstein JA, Cashel M (March 2010). "Imprecise transcription termination within Escherichia coli greA leader gives rise to an array of short transcripts, GraL". Nucleic Acids Research. 38 (5): 1636–1651. doi:10.1093/nar/gkp1150. PMC 2836576. PMID 20008510.
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