Estradiol benzoate butyrate/algestone acetophenide

Estradiol benzoate butyrate/algestone acetophenide, also known as estradiol benzoate butyrate/dihydroxyprogesterone acetophenide (EBB/DHPA) and sold under the brand names Neolutin N, Redimen, Soluna, and Unijab, is a form of combined injectable birth control which is used in Peru and Singapore.[1][2][3][4][5][6] It contains estradiol benzoate butyrate (EBB), an estrogen, and algestone acetophenide (dihydroxyprogesterone acetophenide; DHPA), a progestin.[2][3] The medication is given once per month by injection into muscle.[3]

Estradiol benzoate butyrate /
algestone acetophenide
Combination of
Estradiol benzoate butyrateEstrogen
Algestone acetophenideProgestogen
Clinical data
Trade namesNeolutin N, Redimen, Soluna, Unijab
Other namesEstradiol benzoate butyrate/dihydroxyprogesterone acetophenide; EBB/DHPA; Unimens
Routes of
administration		Intramuscular injection

Medical uses

EBB/DHPA is used as a once-a-month combined injectable contraceptive to prevent pregnancy in women.[1][2][3]

Available forms

EBB/DHPA contains 10 mg estradiol benzoate butyrate (EBB), an estrogen, and 150 mg algestone acetophenide (dihydroxyprogesterone acetophenide; DHPA), a progestin.[2][3]

Pharmacology

Pharmacodynamics

EBB/DHPA has been said to have relatively weak estrogenic activity and has been described as "progestogen-dominant".[1]

Pharmacokinetics

EBB has a shorter duration than estradiol enantate of about 3 weeks.[7] EBB/DHPA was developed because it was thought that the duration of EBB would be more suitable for use as a once-monthly combined injectable contraceptive than estradiol enantate in estradiol enantate/algestone acetophenide.[7]

Society and culture

Brand names

EBB/DHPA is marketed under the brand names Neolutin N, Redimen, Soluna, and Unijab.[1][2][3][4][5][6][8] It was originally developed under the tentative brand name Unimens, but ultimately was not marketed under this particular brand name.[1][7][9][10][11]

Availability

EBB/DHPA is available only in Peru and Singapore.[2][3]

See also

References
  1. Toppozada M (June 1977). "The clinical use of monthly injectable contraceptive preparations". Obstet Gynecol Surv. 32 (6): 335–47. doi:10.1097/00006254-197706000-00001. PMID 865726.
  2. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; World Health Organization; International Agency for Research on Cancer (2007). Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. pp. 433, 467. ISBN 978-92-832-1291-1.
  3. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans; International Agency for Research on Cancer (1 January 1999). Hormonal Contraception and Post-menopausal Hormonal Therapy (PDF). IARC. p. 65. ISBN 978-92-832-1272-0.
  4. https://www.datosperu.org/farmaco-soluna-rs-N12759.php
  5. http://www.mims.com/singapore/drug/info/unijab
  6. http://www.corporacionmisalud.com/sistema/vademecum/PLM/productos/32499.htm
  7. Mokhtar K. Toppozada (1983). "Monthly Injectable Contraceptives". In Alfredo Goldsmith; Mokhtar Toppozada (eds.). Long-Acting Contraception. pp. 93–103. OCLC 35018604.
  8. https://www.drugs.com/international/soluna.html
  9. Elsayed Saad Eldin Hafez (1980). Human reproduction: conception and contraception. Harper and Row. ISBN 978-0-06-141066-6.
  10. Newton JR, D'arcangues C, Hall PE (1994). "A review of "once-a-month" combined injectable contraceptives". J Obstet Gynaecol (Lahore). 4 Suppl 1: S1–34. doi:10.3109/01443619409027641. PMID 12290848.
  11. Toppozada MK (April 1994). "Existing once-a-month combined injectable contraceptives". Contraception. 49 (4): 293–301. doi:10.1016/0010-7824(94)90029-9. PMID 8013216.
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