Ethinylestradiol/megestrol acetate
Ethinylestradiol/megestrol acetate (EE/MGA), sold under the brand name Volidan among others, was a combination of ethinylestradiol (EE), an estrogen, and megestrol acetate (MGA), a progestin, which was used as a birth control pill to prevent pregnancy in women.[1][2] It was taken by mouth and contained 50 to 100 μg EE and 1 to 5 mg MGA per tablet.[2][1] MGA-containing birth control pills were withdrawn after reports in the early 1970s of a high incidence of venous thromboembolism in association with the preparations.[3]
 Ethinylestradiol | |
 Megestrol acetate | |
| Combination of | |
|---|---|
| Ethinylestradiol | Estrogen |
| Megestrol acetate | Progestogen; Progestin |
| Clinical data | |
| Trade names | Nuvacon, Volidan |
| Other names | EE/MGA |
| Routes of administration | By mouth |
| Drug class | Estrogen; Progestin; Progestogen |
| Legal status | |
| Legal status |
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| Identifiers | |
| CAS Number | |
| PubChem CID | |
References
- Lara Marks (2001). Sexual Chemistry: A History of the Contraceptive Pill. Yale University Press. pp. 77–78. ISBN 978-0-300-08943-1.
- Mears E (1963). "A new type of oral contraceptive". Br Med J. 1 (5341): 1318–20. doi:10.1136/bmj.1.5341.1318. PMC 2123904. PMID 13934321.
- El Makhzangy MN, Wynn V, Lawrence DM (January 1979). "Sex hormone binding globulin capacity as an index of oestrogenicity or androgenicity in women on oral contraceptive steroids". Clin Endocrinol (Oxf). 10 (1): 39–45. doi:10.1111/j.1365-2265.1979.tb03031.x. PMID 571314. S2CID 7262495.
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