Ets variant 2

ETV2
Identifiers
Aliases	ETV2, ER71, ETSRP71, Ets variant 2, ETS variant transcription factor 2
External IDs	OMIM: 609358 MGI: 99253 HomoloGene: 7308 GeneCards: ETV2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	35,644,871 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	30,635,852 bp[2]
Gene ontology
Molecular function	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	• cell nucleus;
Biological process	• Notch signaling pathway; • cell differentiation; • positive regulation of endothelial cell differentiation; • regulation of transcription, DNA-templated; • blood vessel morphogenesis; • placentation; • regulation of transcription from RNA polymerase II promoter; • mesoderm formation; • in utero embryonic development; • Wnt signaling pathway; • transcription from RNA polymerase II promoter; • positive regulation of mesoderm development; • positive regulation of gene expression; • BMP signaling pathway involved in mesodermal cell fate specification; • erythrocyte differentiation; • blastocyst development; • positive regulation of transcription from RNA polymerase II promoter; • haematopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	2116
	14008
	ENSG00000105672
	ENSMUSG00000006311
	O00321
	P41163
	NM_001300974; NM_001304549; NM_014209
	NM_007959
	NP_001287903; NP_001291478; NP_055024
	NP_031985
	Wikidata
View/Edit Human	View/Edit Mouse

Ets variant 2 is a protein that in humans is encoded by the ETV2 gene.[5] It is a transcription factor and also plays a role in vascular endothelial cell development.[6]

References

GRCh38: Ensembl release 89: ENSG00000105672 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000006311 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ets variant 2".
Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993. PMID 26694034.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105672 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006311 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ets variant 2".

[6] Oh SY, Kim JY, Park C (December 2015). "The ETS Factor, ETV2: a Master Regulator for Vascular Endothelial Cell Development". Molecules and Cells. 38 (12): 1029–36. doi:10.14348/molcells.2015.0331. PMC 4696993. PMID 26694034.