Exosome component 6

Exosome complex exonuclease MTR3 is an enzyme that in humans is encoded by the EXOSC6 gene.[5][6][7]

EXOSC6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesEXOSC6, EAP4, MTR3, Mtr3p, hMtr3p, p11, Exosome component 6
External IDsOMIM: 606490 MGI: 1919794 HomoloGene: 12469 GeneCards: EXOSC6
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16q22.1Start70,246,778 bp[1]
End70,251,940 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

118460

72544

Ensembl

ENSG00000223496

ENSMUSG00000109941

UniProt

Q5RKV6

Q8BTW3

RefSeq (mRNA)

NM_058219

NM_028274

RefSeq (protein)

NP_478126

NP_082550

Location (UCSC)Chr 16: 70.25 – 70.25 MbChr 8: 111.06 – 111.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene product constitutes one of the subunits of the multisubunit particle called the exosome complex, which mediates mRNA degradation. The composition of human exosome is similar to its yeast counterpart. This protein is homologous to the yeast Mtr3 protein. Its exact function is not known, however, it has been shown using a cell-free RNA decay system that the exosome is required for rapid degradation of unstable mRNAs containing AU-rich elements (AREs), but not for poly(A) shortening. The exosome does not recognize ARE-containing mRNAs on its own, but requires ARE-binding proteins that could interact with the exosome and recruit it to unstable mRNAs, thereby promoting their rapid degradation.[7]

Interactions

Exosome component 6 has been shown to interact with Exosome component 7,[6]Exosome component 8[6] and Exosome component 1.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000223496 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000109941 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Chen CY, Gherzi R, Ong SE, Chan EL, Raijmakers R, Pruijn GJ, Stoecklin G, Moroni C, Mann M, Karin M (Nov 2001). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
  6. Raijmakers R, Egberts WV, van Venrooij WJ, Pruijn GJ (Nov 2002). "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring". J Mol Biol. 323 (4): 653–63. doi:10.1016/S0022-2836(02)00947-6. PMID 12419256.
  7. "Entrez Gene: EXOSC6 exosome component 6".

Further reading


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