FBXW2

Function

F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.[7]

Interactions

FBXW2 has been shown to interact with SKP1A.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000119402 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035949 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. Chiaur DS, Murthy S, Cenciarelli C, Parks W, Loda M, Inghirami G, Demetrick D, Pagano M (Jun 2000). "Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors". Cytogenet Cell Genet. 88 (3–4): 255–8. doi:10.1159/000015532. PMID 10828603. S2CID 431704.
  7. "Entrez Gene: FBXW2 F-box and WD repeat domain containing 2".

Further reading


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