FCRL3

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.[3][4][5]

FCRL3
Identifiers
AliasesFCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDsOMIM: 606510 HomoloGene: 76447 GeneCards: FCRL3
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q23.1Start157,674,321 bp[1]
End157,700,769 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

115352

n/a

Ensembl

ENSG00000160856

n/a

UniProt

Q96P31

n/a

RefSeq (mRNA)

NM_001024667
NM_052939
NM_001320333

n/a

RefSeq (protein)

NP_001307262
NP_443171

n/a

Location (UCSC)Chr 1: 157.67 – 157.7 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[5]

Interactions

FCRL3 has been shown to interact with PTPN6.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000160856 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
  4. Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". The Interface Between Innate and Acquired Immunity. Curr Top Microbiol Immunol. Current Topics in Microbiology and Immunology. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205.
  5. "Entrez Gene: FCRL3 Fc receptor-like 3".
  6. Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

Further reading


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