FCRL3

FCRL3
Identifiers
Aliases	FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDs	OMIM: 606510 HomoloGene: 76447 GeneCards: FCRL3
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	157,700,769 bp[1]
Gene ontology
Molecular function	• kinase binding; • phosphatase binding; • protein phosphatase binding; • protein tyrosine kinase binding;
Cellular component	• membrane; • integral component of membrane; • cell membrane; • cell surface;
Biological process	• negative regulation of immunoglobulin production; • positive regulation of B cell proliferation; • regulation of toll-like receptor 9 signaling pathway; • positive regulation of MAPK cascade; • regulation of B cell differentiation; • negative regulation of B cell receptor signaling pathway; • regulation of B cell activation; • regulation of calcium ion import; • positive regulation of protein serine/threonine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	115352
	n/a
	ENSG00000160856
	n/a
	Q96P31
	n/a
	NM_001024667; NM_052939; NM_001320333
	n/a
	NP_001307262; NP_443171
	n/a
	Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.[3][4][5]

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.[5]

Interactions

FCRL3 has been shown to interact with PTPN6.[6]

References

GRCh38: Ensembl release 89: ENSG00000160856 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". The Interface Between Innate and Acquired Immunity. Curr Top Microbiol Immunol. Current Topics in Microbiology and Immunology. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205.
"Entrez Gene: FCRL3 Fc receptor-like 3".
Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

Miller I, Hatzivassiliou G, Cattoretti G, et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood. 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.
Xu MJ, Zhao R, Cao H, Zhao ZJ (2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. PMID 12051764.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kochi Y, Yamada R, Suzuki A, et al. (2005). "A functional variant in FcRH3, encoding Fc Receptor Homolog 3, is associated with rheumatoid arthritis and several autoimmunities". Nat. Genet. 37 (5): 478–85. doi:10.1038/ng1540. PMC 1362949. PMID 15838509.
Simmonds MJ, Heward JM, Carr-Smith J, et al. (2006). "Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease". J. Clin. Endocrinol. Metab. 91 (3): 1056–61. doi:10.1210/jc.2005-1634. PMID 16384851.
Eyre S, Bowes J, Potter C, et al. (2007). "Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?". Arthritis Research & Therapy. 8 (4): R117. doi:10.1186/ar2006. PMC 1779391. PMID 16859508.
Umemura T, Ota M, Yoshizawa K, et al. (2007). "Lack of association between FCRL3 and FcgammaRII polymorphisms in Japanese type 1 autoimmune hepatitis". Clin. Immunol. 122 (3): 338–42. doi:10.1016/j.clim.2006.08.012. hdl:10091/390. PMID 17020818.
Schäfer N, Blaumeiser B, Becker T, et al. (2007). "Investigation of the functional variant c.-169T > C of the Fc receptor-like 3 (FCRL3) gene in alopecia areata". Int. J. Immunogenet. 33 (6): 393–5. doi:10.1111/j.1744-313X.2006.00633.x. PMID 17117947. S2CID 12420790.
Newman WG, Zhang Q, Liu X, et al. (2007). "Rheumatoid arthritis association with the FCRL3 -169C polymorphism is restricted to PTPN22 1858T-homozygous individuals in a Canadian population". Arthritis Rheum. 54 (12): 3820–7. doi:10.1002/art.22270. PMID 17133579.
Choi CB, Kang CP, Seong SS, et al. (2007). "The -169C/T polymorphism in FCRL3 is not associated with susceptibility to rheumatoid arthritis or systemic lupus erythematosus in a case-control study of Koreans". Arthritis Rheum. 54 (12): 3838–41. doi:10.1002/art.22248. PMID 17133581.
Owen CJ, Kelly H, Eden JA, et al. (2007). "Analysis of the Fc receptor-like-3 (FCRL3) locus in Caucasians with autoimmune disorders suggests a complex pattern of disease association". J. Clin. Endocrinol. Metab. 92 (3): 1106–11. doi:10.1210/jc.2006-2183. PMID 17200162.
Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics. 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841. S2CID 1971426.
Martínez A, Núñez C, Martín MC, et al. (2007). "Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD". Tissue Antigens. 69 (4): 313–7. doi:10.1111/j.1399-0039.2007.00816.x. PMID 17389014.
Martínez A, Mas A, de Las Heras V, et al. (2007). "FcRL3 and multiple sclerosis pathogenesis: role in autoimmunity?". J. Neuroimmunol. 189 (1–2): 132–6. doi:10.1016/j.jneuroim.2007.06.018. PMID 17617473. S2CID 97180.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160856 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11493702-3] Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.

[pmid12014205-4] Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". The Interface Between Innate and Acquired Immunity. Curr Top Microbiol Immunol. Current Topics in Microbiology and Immunology. 266. pp. 85–112. doi:10.1007/978-3-662-04700-2_7. ISBN 978-3-642-07682-4. PMID 12014205.

[entrez-5] "Entrez Gene: FCRL3 Fc receptor-like 3".

[pmid12051764-6] Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3): 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764.

FCRL3

Interactions

References

Further reading