FMNL1

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene.[3][4]

FMNL1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesFMNL1, C17orf1, C17orf1B, FHOD4, FMNL, KW-13, formin like 1
External IDsOMIM: 604656 HomoloGene: 136798 GeneCards: FMNL1
Gene location (Human)
Chr.Chromosome 17 (human)[1]
Band17q21.31Start45,221,444 bp[1]
End45,247,319 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

752

n/a

Ensembl

ENSG00000184922

n/a

UniProt

O95466

n/a

RefSeq (mRNA)

NM_005892

n/a

RefSeq (protein)

NP_005883

n/a

Location (UCSC)Chr 17: 45.22 – 45.25 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice variant has been described but its full length sequence has not been determined.[4]

Interactions

FMNL1 has been shown to interact with Profilin 1,[5] PFN2[5] and RAC1.[5]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000184922 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ (November 1998). "The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17". Hum Genet. 103 (3): 340–345. doi:10.1007/s004390050827. PMID 9799091. S2CID 11305597.
  4. "Entrez Gene: FMNL1 formin-like 1".
  5. Yayoshi-Yamamoto, S; Taniuchi I; Watanabe T (September 2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell motility and survival of macrophages". Mol. Cell. Biol. UNITED STATES. 20 (18): 6872–6881. doi:10.1128/MCB.20.18.6872-6881.2000. ISSN 0270-7306. PMC 86228. PMID 10958683.

Further reading


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