FRAT2

GSK-3-binding protein FRAT2 is a protein that in humans is encoded by the FRAT2 gene.[5][6][7]

FRAT2
Identifiers
AliasesFRAT2, WNT signaling pathway regulator, FRAT-2, FRAT regulator of WNT signaling pathway 2
External IDsOMIM: 605006 MGI: 2673967 HomoloGene: 8095 GeneCards: FRAT2
Gene location (Human)
Chr.Chromosome 10 (human)[1]
Band10q24.1Start97,332,497 bp[1]
End97,334,729 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

23401

212398

Ensembl

ENSG00000181274

ENSMUSG00000047604

UniProt

O75474

Q8K025

RefSeq (mRNA)

NM_012083

NM_177603

RefSeq (protein)

NP_036215

NP_808271

Location (UCSC)Chr 10: 97.33 – 97.33 MbChr 19: 41.85 – 41.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000181274 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000047604 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Yost C, Farr GH 3rd, Pierce SB, Ferkey DM, Chen MM, Kimelman D (Jul 1998). "GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis". Cell. 93 (6): 1031–41. doi:10.1016/S0092-8674(00)81208-8. PMID 9635432. S2CID 17951152.
  6. Saitoh T, Moriwaki J, Koike J, Takagi A, Miwa T, Shiokawa K, Katoh M (Mar 2001). "Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway". Biochem Biophys Res Commun. 281 (3): 815–20. doi:10.1006/bbrc.2001.4421. PMID 11237732.
  7. "Entrez Gene: FRAT2 frequently rearranged in advanced T-cell lymphomas 2".

Further reading


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