Ferroxidase

Ferroxidase also known as Fe(II):oxygen oxidoreductase is an enzyme that catalyzes the oxidization of iron II to iron III:

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2H2O
Ferroxidase
Identifiers
EC number1.16.3.1
CAS number9031-37-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

Examples

Human genes encoding proteins with ferroxidase activity include:

  • CP – Ceruloplasmin
  • FTH1 – Ferritin heavy chain
  • FTMT – Ferritin, mitochondrial
  • HEPH - Hephaestin

References
  • Cox JC, Boxer DH (1986). "The role of rusticyanin, a blue copper protein, in the electron transport chain of Thiobacillus ferrooxidans grown on iron or thiosulfate". Biotechnol. Appl. Biochem. 8: 269–275.
  • Osaki S (November 1966). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)". J. Biol. Chem. 241 (21): 5053–9. PMID 5925868.
  • Osaki S, Walaas O (June 1967). "Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase. II. Rate constants at various steps and formation of a possible enzyme-substrate complex". J. Biol. Chem. 242 (11): 2653–7. PMID 6027241.


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