Fluticasone
Fluticasone are two manufactured steroids used to treat nasal symptoms.[1][2][3][4][5] Both the esters, fluticasone furoate and fluticasone propionate, are also used as topical anti-inflammatories and inhaled corticosteroids, and are used much more commonly in comparison.[3][2][4][6]
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Other names | 6α,9α-Difluoro-11β,17α-dihydroxy-16α-methyl-21-thia-21-fluoromethylpregna-1,4-dien-3,20-dione; S-(Fluoromethyl)-6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate |
Routes of administration | Intranasal, inhaled, topical |
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Bioavailability | 0.51% (Intranasal) |
Protein binding | 91.0% |
Metabolism | Intranasal Liver (CYP3A4-mediated) |
Elimination half-life | 10 hours |
Excretion | Eye |
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Formula | C22H27F3O4S |
Molar mass | 444.51 g·mol−1 |
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The route of administration varies, but often it is inhaled intranasally. It may use an exhalation delivery system.
In 2017, it was the fifteenth most commonly prescribed medication in the United States, with more than 32 million prescriptions.[7][8]
See also
References
- Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 574–. ISBN 978-1-4757-2085-3.
- Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 1337–. ISBN 978-3-88763-075-1.
- Morton IK, Hall JM (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 124–. ISBN 978-94-011-4439-1.
- https://www.drugs.com/international/fluticasone.html
- Briggs GG, Freeman RK, Yaffe SJ (2012). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 600. ISBN 978-1451153590.
- Spratto GR, Woods AL (2012). Delmar Nurse's Drug Handbook 2012. Cengage Learning. p. 748. ISBN 978-1111310653.
- "The Top 300 of 2020". ClinCalc—. Retrieved 11 April 2020.
- "Fluticasone - Drug Usage Statistics". ClinCalc. 23 December 2019. Retrieved 11 April 2020.
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