Formyl-CoA transferase

In enzymology, a formyl-CoA transferase (EC 2.8.3.16) is an enzyme that catalyzes the chemical reaction

formyl-CoA + oxalate formate + oxalyl-CoA
Formyl-CoA transferase
Identifiers
EC number2.8.3.16
CAS number128826-27-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Thus, the two substrates of this enzyme are formyl-CoA and oxalate, whereas its two products are formate and oxalyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is formyl-CoA:oxalate CoA-transferase. Other names in common use include formyl-coenzyme A transferase, and formyl-CoA oxalate CoA-transferase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1T3Z, 1T4C, 1VGQ, and 1VGR.

References

    • Baetz AL, Allison MJ (1990). "Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes". J. Bacteriol. 172 (7): 3537–40. doi:10.1128/jb.172.7.3537-3540.1990. PMC 213325. PMID 2361939.
    • Sidhu H, Ogden SD, Lung HY, Luttge BG, Baetz AL, Peck AB (1997). "DNA sequencing and expression of the formyl coenzyme A transferase gene, frc, from Oxalobacter formigenes". J. Bacteriol. 179 (10): 3378–81. doi:10.1128/jb.179.10.3378-3381.1997. PMC 179125. PMID 9150242.


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