Fox Chase Cancer Center

A short history of notable achievements by Fox Chase researchers:

• 2011 The 6th Albert Szent-Györgyi Prize for Progress in Cancer Research was awarded to Beatrice Mintz by the National Foundation for Cancer Research for her discoveries of the relationship between development and cancer, based on construction and analysis of chimeric and transgenic mouse models.
• 2004 The Kyoto Prize in Basic Science is awarded to Alfred G. Knudson for lifetime achievement and contributions to the betterment of mankind.
• 2004 The Nobel Prize in Chemistry is awarded to Irwin Rose and his colleagues Aaron Ciechanover and Avram Hershko for their discovery of ubiquitin-mediated protein degradation.
• 1993 Beatrice Mintz produces the first mouse model of human malignant melanoma, in which the disease resembles the human malignancy.
• 1991 Philip Tsichlis, Alfonso Bellacosa, and Joseph Testa clone the AKT1 and AKT2 genes - the first viral oncogenes described that inhibit programmed cell death.
• 1991 Timothy Yen discovers that a molecular motor controls the way human cells sort their chromosomes when cells divide during mitosis.
• 1982 William Mason and Jesse Summers demonstrate that the hepatitis B virus utilizes reverse transcription for genome replication, previously thought to be unique to retroviruses.
• 1981 Beatrice Mintz's laboratory is one of the first to introduce a cloned gene into fertilized mouse eggs and prove that it is retained in animals developing from those eggs, and is transmitted to their progeny.
• 1980 Discovery of critical aspects of ubiquitin-dependent protein degradation by Avram Hershko and Irwin Rose.
• 1980 Alfred G. Knudson develops the "two-hit" hypothesis, predicting the existence and behavior of tumor suppressor genes.
• 1980 Discovery of the SCID mouse, a mouse strain with no natural immunity, by Melvin Bosma. The SCID mouse is an essential research tool in devising new treatments.
• 1979 Beatrice Mintz shows that a fatal genetic anemia of mice can be prevented in utero by injecting normal blood-forming stem cells into the fetus through a placental blood vessel.
• 1976 The Nobel Prize in Physiology or Medicine is awarded to Baruch Blumberg for his discovery of the Hepatitis B virus and development of the HBV vaccine, the first "anti-cancer vaccine", which has reduced the incidence of liver cancer.
• 1975 The first transgenic mammals containing foreign DNA are produced by Beatrice Mintz and Rudolf Jaenisch.
• 1974 Discovery by Robert Perry that the messenger RNAs of mammalian cells and their precursors contain a novel structure at their leading ends.
• 1972 Helen Berman and Jenny Glusker report the crystal structure of a nucleic acid-drug complex as a model for anti-tumor agent and mutagen action.
• 1968 Development of the first Hepatitis B vaccine by Baruch Blumberg and Irving Millman.
• 1967 Discovery of the Hepatitis B virus and development of the blood test for Hepatitis B by Baruch Blumberg.
• 1962 The first demonstration, by Robert Perry, that ribosomal RNA is synthesized in the nucleolus as a large precursor molecule that is subsequently processed into mature components.
• 1962 Beatrice Mintz's development of the first mammal comprising two genetically different cell populations in all tissues, as a tool for analyses of embryonic development and disease in mouse models.
• 1960 Discovery of the Philadelphia chromosome, the first genetic abnormality associated with a human cancer, by David Hungerford of the Fox Chase Cancer Center and Peter Nowell of the University of Pennsylvania.
• 1952 First nuclear transplantation (or 'cloning') experiment is performed by Robert Briggs and Thomas King using eggs of the frog Rana pipiens.
• 1946 Mary Bennett identifies an essential nutrient later revealed to be Vitamin B12.

• Manfred Bayer, electron microscopist who obtained the earliest images of hepatitis B virus
• Helen M. Berman, former director of the Protein Data Bank
• Baruch Blumberg, (d. 5 April 2011) awarded the Nobel Prize in Physiology or Medicine in 1976 for discovery of Hepatitis B and the Hepatitis B vaccine
• Wafik El-Deiry, discoverer of WAF1
• Jenny Pickworth Glusker, noted crystallographer
• V. Craig Jordan, "Father of Tamoxifen"
• Alfred G. Knudson, architect of the "two-hit hypothesis" (Knudson hypothesis) about the role of accumulated genetic errors in cancer development, awarded the Kyoto Prize in 2004 and the Albert Lasker Award in 1998
• H. Paul Meloche (1929 – 1999), research biochemist who specialized in the field of enzyme stereochemistry
• Irving Millman (d. 17 April 2012), who helped Baruch Blumberg develop the first hepatitis B vaccine
• Beatrice Mintz, pioneering female cancer researcher, noted for many embryonic and genetic advances, and member of the National Academy of Sciences and of the Pontifical Academy of Sciences
• Arthur Lindo Patterson, who developed the Patterson function, a key step in determining the structures of molecules using X-ray crystallography
• Irwin Rose, awarded Nobel Prize in Chemistry in 2004 for the discovery of ubiquitin-mediated protein degradation
• Harry Rozmiarek, noted veterinarian, academic, and laboratory animal care specialist.
• Shirley M. Tilghman, president of Princeton University from 2001 to 2013

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