GBP1

Interferon-induced guanylate-binding protein 1 is a protein that in humans is encoded by the GBP1 gene.[3][4] It belongs to the dynamin superfamily of large GTPases.[5]

GBP1
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesGBP1, guanylate binding protein 1
External IDsOMIM: 600411 HomoloGene: 133759 GeneCards: GBP1
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1p22.2Start89,052,319 bp[1]
End89,065,230 bp[1]
RNA expression pattern


More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

2633

n/a

Ensembl

ENSG00000117228

n/a

UniProt

P32455

n/a

RefSeq (mRNA)

NM_002053

n/a

RefSeq (protein)

NP_002044

n/a

Location (UCSC)Chr 1: 89.05 – 89.07 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.[4]

References

  1. GRCh38: Ensembl release 89: ENSG00000117228 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Strehlow I, Lohmann-Matthes ML, Decker T (Aug 1994). "The interferon-inducible GBP1 gene: structure and mapping to human chromosome 1". Gene. 144 (2): 295–9. doi:10.1016/0378-1119(94)90393-X. PMID 7518790.
  4. "Entrez Gene: GBP1 guanylate binding protein 1, interferon-inducible, 67kDa".
  5. Praefcke GJ, McMahon HT (February 2004). "The dynamin superfamily: universal membrane tubulation and fission molecules?". Nat. Rev. Mol. Cell Biol. 5 (2): 133–47. doi:10.1038/nrm1313. PMID 15040446. S2CID 6305282.

Further reading


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