GCC1

GRIP and coiled-coil domain-containing protein 1 is a protein that in humans is encoded by the GCC1 gene.[4][5]

GCC1
Identifiers
AliasesGCC1, GCC1P, GCC88, GRIP and coiled-coil domain containing 1
External IDsOMIM: 607418 MGI: 1921625 HomoloGene: 11567 GeneCards: GCC1
Gene location (Human)
Chr.Chromosome 7 (human)[1]
Band7q32.1Start127,580,628 bp[1]
End127,593,611 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

79571

74375

Ensembl

ENSG00000179562

ENSMUSG00000029708

UniProt

Q96CN9

Q9D4H2

RefSeq (mRNA)

NM_024523

NM_028900

RefSeq (protein)

NP_078799

NP_083176

Location (UCSC)Chr 7: 127.58 – 127.59 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport.[5]

Interactions

GCC1 has been shown to interact with TRIM29.[6]

References

  1. GRCh38: Ensembl release 89: ENSG00000179562 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Kjer-Nielsen L, Teasdale RD, van Vliet C, Gleeson PA (May 1999). "A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins". Curr. Biol. 9 (7): 385–8. doi:10.1016/S0960-9822(99)80168-7. PMID 10209125. S2CID 14342088.
  5. "Entrez Gene: GCC1 GRIP and coiled-coil domain containing 1".
  6. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading


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