GCC2

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene.[4][5]

GCC2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGCC2, GCC185, RANBP2L4, REN53, GRIP and coiled-coil domain containing 2
External IDsOMIM: 612711 MGI: 1917547 HomoloGene: 45639 GeneCards: GCC2
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q12.3Start108,449,191 bp[1]
End108,509,415 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

9648

70297

Ensembl

ENSG00000135968

ENSMUSG00000038039

UniProt

Q8IWJ2

Q8CHG3

RefSeq (mRNA)

NM_181453

NM_027375

RefSeq (protein)

NP_852118

n/a

Location (UCSC)Chr 2: 108.45 – 108.51 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a peripheral membrane protein localized to the trans-Golgi network. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[5]

References

  1. GRCh38: Ensembl release 89: ENSG00000135968 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Luke MR, Kjer-Nielsen L, Brown DL, Stow JL, Gleeson PA (Feb 2003). "GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network". J Biol Chem. 278 (6): 4216–26. doi:10.1074/jbc.M210387200. PMID 12446665.
  5. "Entrez Gene: GCC2 GRIP and coiled-coil domain containing 2".

Further reading


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