GFM2

GFM2
Identifiers
Aliases	GFM2, EF-G2mt, EFG2, MRRF2, MST027, RRF2, RRF2mt, hEFG2, mEF-G 2, MSTP027, G elongation factor, mitochondrial 2, G elongation factor mitochondrial 2, RRF, GTP dependent ribosome recycling factor mitochondrial 2
External IDs	OMIM: 606544 MGI: 2444783 HomoloGene: 6238 GeneCards: GFM2
Gene location (Human)
Chr.	Chromosome 5 (human)[1]
End	74,767,147 bp[1]
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)[2]
End	97,181,195 bp[2]
Gene ontology
Molecular function	• translation elongation factor activity; • nucleotide binding; • GTP binding; • GO:0001948 protein binding; • GTPase activity;
Cellular component	• mitochondrial matrix; • mitochondrion;
Biological process	• mitochondrial translational termination; • mitochondrial translational elongation; • ribosome disassembly; • protein biosynthesis; • mitochondrial translation; • translational elongation;
	Sources:Amigo / QuickGO
Orthologs
	84340
	320806
	ENSG00000164347
	ENSMUSG00000021666
	Q969S9
	Q8R2Q4
	NM_001281302; NM_032380; NM_170681; NM_170691
	NM_001146043; NM_001271463; NM_001271464; NM_001271465; NM_177266
	NP_001268231; NP_115756; NP_733781; NP_733792; NP_733792.1
	NP_001139515; NP_001258392; NP_001258393; NP_001258394; NP_796240
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. [5][6] Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.[7]

References

GRCh38: Ensembl release 89: ENSG00000164347 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021666 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.
"Entrez Gene: GFM2 G elongation factor, mitochondrial 2".
Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.

External links

InterPro: IPR030851

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164347 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021666 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11735030-5] Hammarsund M, Wilson W, Corcoran M, Merup M, Einhorn S, Grandér D, Sangfelt O (November 2001). "Identification and characterization of two novel human mitochondrial elongation factor genes, hEFG2 and hEFG1, phylogenetically conserved through evolution". Human Genetics. 109 (5): 542–50. doi:10.1007/s00439-001-0610-5. PMID 11735030. S2CID 24508386.

[entrez-6] "Entrez Gene: GFM2 G elongation factor, mitochondrial 2".

[7] Tsuboi M, Morita H, Nozaki Y, Akama K, Ueda T, Ito K, Nierhaus KH, Takeuchi N (August 2009). "EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis". Molecular Cell. 35 (4): 502–10. doi:10.1016/j.molcel.2009.06.028. PMID 19716793.