GOLGA4

Golgin subfamily A member 4 is a protein that in humans is encoded by the GOLGA4 gene.[5][6]

GOLGA4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGOLGA4, CRPF46, GCP2, GOLG, MU-RMS-40.18, golgin A4, Trans-GolgiI p230, Golgin 245, p230
External IDsOMIM: 602509 MGI: 1859646 HomoloGene: 68224 GeneCards: GOLGA4
Gene location (Human)
Chr.Chromosome 3 (human)[1]
Band3p22.2Start37,243,177 bp[1]
End37,366,751 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

2803

54214

Ensembl

ENSG00000144674

ENSMUSG00000038708

UniProt

Q13439
Q49A56

Q91VW5

RefSeq (mRNA)

NM_001172713
NM_002078

NM_018748

RefSeq (protein)

NP_001166184
NP_002069
NP_001166184.1
NP_002069.2

NP_061218

Location (UCSC)Chr 3: 37.24 – 37.37 MbChr 9: 118.51 – 118.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. This protein has been postulated to play a role in Rab6-regulated membrane-tethering events in the Golgi apparatus. Alternative splice variants have been described but their full-length nature has not been determined.[6]

Interactions

GOLGA4 has been shown to interact with ARL1.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000144674 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000038708 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Erlich R, Gleeson PA, Campbell P, Dietzsch E, Toh BH (June 1996). "Molecular characterization of trans-Golgi p230. A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif". J Biol Chem. 271 (14): 8328–8337. doi:10.1074/jbc.271.14.8328. PMID 8626529.
  6. "Entrez Gene: GOLGA4 golgi autoantigen, golgin subfamily a, 4".
  7. Lu, Lei; Hong Wanjin (September 2003). "Interaction of Arl1-GTP with GRIP Domains Recruits Autoantigens Golgin-97 and Golgin-245/p230 onto the Golgi". Mol. Biol. Cell. 14 (9): 3767–3781. doi:10.1091/mbc.E03-01-0864. ISSN 1059-1524. PMC 196566. PMID 12972563.
  8. Van Valkenburgh, H; Shern J F; Sharer J D; Zhu X; Kahn R A (June 2001). "ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins". J. Biol. Chem. 276 (25): 22826–22837. doi:10.1074/jbc.M102359200. ISSN 0021-9258. PMID 11303027.

Further reading


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