GPAA1

Glycosylphosphatidylinositol anchor attachment 1 protein is a protein that in humans is encoded by the GPAA1 gene.[5][6]

GPAA1
Identifiers
AliasesGPAA1, GAA1, hGAA1, glycosylphosphatidylinositol anchor attachment 1, GPIBD15
External IDsOMIM: 603048 MGI: 1202392 HomoloGene: 37852 GeneCards: GPAA1
Gene location (Human)
Chr.Chromosome 8 (human)[1]
Band8q24.3Start144,082,590 bp[1]
End144,086,216 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

8733

14731

Ensembl

ENSG00000197858

ENSMUSG00000022561

UniProt

O43292

Q9WTK3

RefSeq (mRNA)

NM_003801

NM_010331

RefSeq (protein)

NP_003792

NP_034461

Location (UCSC)Chr 8: 144.08 – 144.09 MbChr 15: 76.33 – 76.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.[6]

Interactions

GPAA1 has been shown to interact with PIGT[7][8] and PIGK.[8][9]

References

  1. GRCh38: Ensembl release 89: ENSG00000197858 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000022561 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hiroi Y, Komuro I, Matsushita I, Aburatani H, Hosoda T, Nakahori Y, et al. (December 1998). "Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24". Genomics. 54 (2): 354–5. doi:10.1006/geno.1998.5490. PMID 9828142.
  6. "Entrez Gene: GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)".
  7. Ohishi K, Inoue N, Kinoshita T (August 2001). "PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8". The EMBO Journal. 20 (15): 4088–98. doi:10.1093/emboj/20.15.4088. PMC 149153. PMID 11483512.
  8. Vainauskas S, Maeda Y, Kurniawan H, Kinoshita T, Menon AK (August 2002). "Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex". The Journal of Biological Chemistry. 277 (34): 30535–42. doi:10.1074/jbc.M205402200. PMID 12052837.
  9. Ohishi K, Inoue N, Maeda Y, Takeda J, Riezman H, Kinoshita T (May 2000). "Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins". Molecular Biology of the Cell. 11 (5): 1523–33. doi:10.1091/mbc.11.5.1523. PMC 14864. PMID 10793132.

Further reading


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