GRAMD4

GRAM domain containing 4 (GRAMD4) also known as Death-Inducing Protein (DIP) is a protein that is encoded by the GRAMD4 gene.[5][6]

GRAMD4
Identifiers
AliasesGRAMD4, DIP, dA59H18.1, dJ439F8.1, GRAM domain containing 4
External IDsOMIM: 613691 MGI: 2676308 HomoloGene: 18199 GeneCards: GRAMD4
Gene location (Human)
Chr.Chromosome 22 (human)[1]
Band22q13.31Start46,576,012 bp[1]
End46,679,790 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

23151

223752

Ensembl

ENSG00000075240

ENSMUSG00000035900

UniProt

Q6IC98

Q8CB44

RefSeq (mRNA)

NM_015124
NM_001366660

NM_001205353
NM_172611
NM_001379572

RefSeq (protein)

NP_055939
NP_001353589

NP_001192282
NP_766199
NP_001366501

Location (UCSC)Chr 22: 46.58 – 46.68 MbChr 15: 86.06 – 86.14 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis.[7]

References

  1. GRCh38: Ensembl release 89: ENSG00000075240 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000035900 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: GRAM domain containing 4". Retrieved 2017-05-16.
  6. "RecName: Full=GRAM domain-containing protein 4; AltName: Full=Death-inducing protein". Retrieved 2020-03-07.
  7. Stanelle J, Tu-Rapp H, Pützer BM (2005). "A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53". Cell Death Differ. 12 (4): 347–57. doi:10.1038/sj.cdd.4401532. PMID 15565177.

Further reading


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