GTF2A1L

GTF2A1L
Identifiers
Aliases	GTF2A1L, ALF, general transcription factor IIA subunit 1 like
External IDs	OMIM: 605358 MGI: 1919078 HomoloGene: 86732 GeneCards: GTF2A1L
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	48,733,148 bp[1]
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)[2]
End	88,715,152 bp[2]
Gene ontology
Molecular function	• DNA binding; • GO:0001105 transcription coactivator activity; • GO:0001948 protein binding;
Cellular component	• transcription factor TFIIA complex; • cell nucleus; • cytoplasm;
Biological process	• transcription initiation from RNA polymerase II promoter; • regulation of transcription, DNA-templated; • transcription from RNA polymerase II promoter; • cognition; • transcription, DNA-templated; • positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	11036
	71828
	ENSG00000242441
	ENSMUSG00000024154
	Q9UNN4
	Q8R4I4
	NM_172196; NM_001193487; NM_006872
	NM_023630
	NP_001180416; NP_006863
	NP_076119
	Wikidata
View/Edit Human	View/Edit Mouse

TFIIA-alpha and beta-like factor is a protein that in humans is encoded by the GTF2A1L gene.[5][6][7][8]

The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of TFIIA on the interaction between TATA-binding protein (TBP) and DNA.

This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified.

Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein consisting of sequence sharing identity with each individual gene product.[8]

References

GRCh38: Ensembl release 89: ENSG00000242441 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000024154 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi:10.1074/jbc.274.25.18040. PMID 10364255.
Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi:10.1074/jbc.M200954200. PMID 11889132.
Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi:10.3892/ijmm.17.4.599. PMID 16525715.
"Entrez Gene: ALF TFIIA-alpha/beta-like factor".

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. doi:10.1093/nar/24.14.2813. PMC 145994. PMID 8759016.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Malik S, Guermah M, Roeder RG (1998). "A dynamic model for PC4 coactivator function in RNA polymerase II transcription". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2192–7. doi:10.1073/pnas.95.5.2192. PMC 19292. PMID 9482861.
Han SY, Zhou L, Upadhyaya A, et al. (2001). "TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse". Biol. Reprod. 64 (2): 507–17. doi:10.1095/biolreprod64.2.507. PMID 11159353.
Yoshida S, Ohbo K, Takakura A, et al. (2002). "Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice". Dev. Biol. 240 (2): 517–30. doi:10.1006/dbio.2001.0473. PMID 11784080.
Upadhyaya AB, Khan M, Mou TC, et al. (2002). "The germ cell-specific transcription factor ALF. Structural properties and stabilization of the TATA-binding protein (TBP)-DNA complex". J. Biol. Chem. 277 (37): 34208–16. doi:10.1074/jbc.M204808200. PMID 12107178.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Howe ML, Mehmud ZF, Saha S, et al. (2006). "Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo". Stem Cells Dev. 15 (2): 175–90. doi:10.1089/scd.2006.15.175. PMID 16646664.
Kim M, Li D, Cui Y, et al. (2006). "Regulatory factor interactions and somatic silencing of the germ cell-specific ALF gene". J. Biol. Chem. 281 (45): 34288–98. doi:10.1074/jbc.M607168200. PMID 16966320.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000242441 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024154 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10364255-5] Upadhyaya AB, Lee SH, DeJong J (Jul 1999). "Identification of a general transcription factor TFIIAalpha/beta homolog selectively expressed in testis". J Biol Chem. 274 (25): 18040–8. doi:10.1074/jbc.274.25.18040. PMID 10364255.

[pmid11889132-6] Xie W, Han S, Khan M, DeJong J (May 2002). "Regulation of ALF gene expression in somatic and male germ line tissues involves partial and site-specific patterns of methylation". J Biol Chem. 277 (20): 17765–74. doi:10.1074/jbc.M200954200. PMID 11889132.

[pmid16525715-7] Huang M, Wang H, Li J, Zhou Z, Du Y, Lin M, Sha J (Mar 2006). "Involvement of ALF in human spermatogenesis and male infertility". Int J Mol Med. 17 (4): 599–604. doi:10.3892/ijmm.17.4.599. PMID 16525715.

[entrez-8] "Entrez Gene: ALF TFIIA-alpha/beta-like factor".

GTF2A1L

References

Further reading