G protein nucleolar 3 like
G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.[5]
Function
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.
References
- GRCh38: Ensembl release 89: ENSG00000130119 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000025266 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: G protein nucleolar 3 like". Retrieved 2017-10-23.
Further reading
- Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006). "The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA". Mol. Biol. Cell. 17 (1): 460–74. doi:10.1091/mbc.E05-09-0848. PMC 1345682. PMID 16251348.
- Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID 17034816.
- Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID 21063916.
- Meng L, Hsu JK, Tsai RY (2011). "GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest". Oncogene. 30 (14): 1716–26. doi:10.1038/onc.2010.550. PMC 3072457. PMID 21132010.
- Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMC 6519424. PMID 24610951.
- Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015). "GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLoS ONE. 10 (8): e0135845. doi:10.1371/journal.pone.0135845. PMC 4537249. PMID 26274615.
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