Galectin-7

Galectin-7 is a protein that in humans is encoded by the LGALS7 gene.[5][6][7]

LGALS7
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLGALS7, GAL7, LGALS7A, galectin 7
External IDsOMIM: 600615 MGI: 1316742 HomoloGene: 100509 GeneCards: LGALS7
Gene location (Human)
Chr.Chromosome 19 (human)[1]
Band19q13.2Start38,770,971 bp[1]
End38,773,492 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

3963

16858

Ensembl

ENSG00000283082
ENSG00000205076

ENSMUSG00000053522

UniProt

P47929

O54974

RefSeq (mRNA)

NM_002307

NM_008496

RefSeq (protein)

NP_002298
NP_001035972

n/a

Location (UCSC)Chr 19: 38.77 – 38.77 MbChr 7: 28.86 – 28.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Differential and in situ hybridizations indicate that this lectin is specifically expressed in keratinocytes. It is expressed at all stages of epidermal differentiation (i.e., in basal and suprabasal layers). It is moderately repressed by retinoic acid. The protein was found mainly in stratified squamous epithelium. The antigen localized to basal keratinocytes, although it was also found, albeit at lower levels, in the suprabasal layers where it concentrated to areas of cell-to-cell contact. The cellular localization and its striking down-regulation in cultured keratinocytes imply a role in cell–cell and/or cell–matrix interactions necessary for normal growth control.[7]

References

  1. ENSG00000205076 GRCh38: Ensembl release 89: ENSG00000283082, ENSG00000205076 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000053522 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Madsen P, Rasmussen HH, Flint T, Gromov P, Kruse TA, Honore B, Vorum H, Celis JE (Apr 1995). "Cloning, expression, and chromosome mapping of human galectin-7". J Biol Chem. 270 (11): 5823–29. doi:10.1074/jbc.270.11.5823. PMID 7534301.
  6. Magnaldo T, Bernerd F, Darmon M (May 1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
  7. "Entrez Gene: LGALS7 lectin, galactoside-binding, soluble, 7 (galectin 7)".

Further reading


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